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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 3 | Page No.: 300-303
DOI: 10.3923/jpt.2007.300.303
 
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Studies on the Biochemical Effects of Talinum triangulare in Rat

Arit Ekpo, Olorunfemi Eseyin, Ndukwe Kalu, Obot Jackson and E.J. Edoho

Abstract:
Ethanol extract of Talinum triangulare was administered parenterally to Wistar albino rats weighing 144-179 g daily for a period of twenty eight days at four dose levels: 100, 250, 500 and 1000 mg kg-1. Control group received saline water only in place of the extract. The rats were fasted overnight after extract administration on the 28th day. On the 29th day the rats were dissected under chloroform anaesthesia and blood collected by cardiac puncture. Serum was obtained from the blood by centrifugation after clotting. The concentration of the following enzymes and biomolecules were determined from the serum using appropriatre commercial kit (Randox R, United Kingdom): Alanine and aspartate aminotransferases, alkaline phosphatases, total cholesterol, high density lipoproteins, triglycerides, creatinine, total proteins, total and conjugated bilirubin and glucose. The extract significantly reduced the concentration of creatinine to 105.0, 94.20, 100.20 and 82.00 mmol L-1 from control level of 134.44 mmol L-1 and increased glucose concentration to 81.0, 76.8, 82.0 and 72.8 mg dL-1 compared to control at all dose levels (100, 250, 500 and 1000 mg kg-1, respectively). Changes in concentration of all the other biomolecules were insignificant at p< 0.05. The results showed that Talinum triangulare possesses hemolytic and hyperglycemic effect and should therefore be consumed with caution by diabetic patients.
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How to cite this article:

Arit Ekpo, Olorunfemi Eseyin, Ndukwe Kalu, Obot Jackson and E.J. Edoho, 2007. Studies on the Biochemical Effects of Talinum triangulare in Rat. Journal of Pharmacology and Toxicology, 2: 300-303.

DOI: 10.3923/jpt.2007.300.303

URL: https://scialert.net/abstract/?doi=jpt.2007.300.303

COMMENTS
30 March, 2010
AKINTUNDE OLUKAYODE GBOLAHAN :
This is a good job i want the materials and method of this work. It will help in my further studies on Talinum triangulare project work on commercial laying birds Gallus gallus,Thanks.
07 July, 2011
BANKOLE MARC MOBOLADJI:

I am a beninese. I am studing Pharmacy. This is a good work. I recognize that. It will help me in my studies on Talinum triangulare.

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