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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 3 | Page No.: 220-237
DOI: 10.3923/jpt.2007.220.237
 
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Phytochemical and Toxicological Studies of Zygophyllum album L.f.

Amal M.Y. Moustafa, Ahmed I. Khodair, Faiza M. Hammouda and Husseiny A. Husseiny

Abstract:
Investigation of the chemical constituents of Zygophyllum album L.f. (Zygophyllaceae family) let to isolate three flavonoids via Kaempferol, Isorhamnetin and Quercetin-3-O-glucoside, one β-carboline alkaloids; Harmine, 16 n-alkanes (C12-C32), β-amyrin, stigmasterol and β-sitosterol and nine fatty acids. The stucctures of these compounds were established by Mass spectrometry (MS), Gas-liquid chromatography (GLC) and spectroscopic techniques, including Ultra-violet (UV), Infra-red (IR) and Nuclear Magnetic Resonance spectroscopic analysis (1H NMR). The oral LD50±standard error and their 95% fiducial limits of the total alcoholic extract were 5.9±0.25 and (5.59-6.23) g kg-1 bw, respectively. While, the intra peritoneal LD50±standard error and their 95% fiducial limits of the extract were 2.60±0.15 and (2.44-2.77) g kg-1 bw, respectively. The total alcoholic extract of the plant could be highly toxic for rats. The extrapolated calculation to human revealed that, this plant could be considered as slightly toxic for man.
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How to cite this article:

Amal M.Y. Moustafa, Ahmed I. Khodair, Faiza M. Hammouda and Husseiny A. Husseiny, 2007. Phytochemical and Toxicological Studies of Zygophyllum album L.f.. Journal of Pharmacology and Toxicology, 2: 220-237.

DOI: 10.3923/jpt.2007.220.237

URL: https://scialert.net/abstract/?doi=jpt.2007.220.237

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