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Journal of Pharmacology and Toxicology

Year: 2007 | Volume: 2 | Issue: 3 | Page No.: 220-237
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Authors

Amal M.Y. Moustafa

Ahmed I. Khodair

Faiza M. Hammouda

Husseiny A. Husseiny

Keywords

Investigation of the chemical constituents of Zygophyllum album L.f. (Zygophyllaceae family) let to isolate three flavonoids via Kaempferol, Isorhamnetin and Quercetin-3-O-glucoside, one β-carboline alkaloids; Harmine, 16 n-alkanes (C12-C32), β-amyrin, stigmasterol and β-sitosterol and nine fatty acids. The stucctures of these compounds were established by Mass spectrometry (MS), Gas-liquid chromatography (GLC) and spectroscopic techniques, including Ultra-violet (UV), Infra-red (IR) and Nuclear Magnetic Resonance spectroscopic analysis (1H NMR). The oral LD50±standard error and their 95% fiducial limits of the total alcoholic extract were 5.9±0.25 and (5.59-6.23) g kg-1 bw, respectively. While, the intra peritoneal LD50±standard error and their 95% fiducial limits of the extract were 2.60±0.15 and (2.44-2.77) g kg-1 bw, respectively. The total alcoholic extract of the plant could be highly toxic for rats. The extrapolated calculation to human revealed that, this plant could be considered as slightly toxic for man.
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