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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 1 | Page No.: 1-19
DOI: 10.3923/jpt.2007.1.19
Role of Anserine and/or Zinc in Modulating Nucleic Acid and Protein Disorders in Rats Exposed to Gamma Irradiation
Hanan F. Ali, Laila M. Faddah, Maha Z. Rizk and Hisham El-Ebiary

Abstract:
In view of radiation injuries to tissues, the present study was carried out to provide information on the deteriorative effects induced by γ-irradiation (5.7Gy) after 24 h and 14 days and to determine both the prophylactic and curative influences of intraperitoneally administered anserine and/or zinc on liver nucleic acids and on total serum total protein, albumin and also different serum protein fractions, namely, prealbumin, α- and β-lipoproteins, α-1 antitrypsin, α-1 acidic glycoprotein, α-1 macroglobulin, cholinesterase, transferrin, ceruloplasmin, haptoglobin and haemopexin. The data obtained revealed that all liver and serum parameters measured significantly declined in rats exposed to whole body irradiation in the two time phases except for the lipoprotein fractions. Administration of anserine and/or zinc either pre or post radiation dose induced a significant improvement in all parameters. It could be concluded that either anserine or zinc has a pronounced effect in overcoming the disturbances induced by γ-irradiation especially when administered post irradiation and the action of each can be potentiated by supplementation of the other. It is thus recommended to use a collective combination of both anserine and zinc as radioprotectors as well as for treatment of radiation hazards.
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How to cite this article:

Hanan F. Ali, Laila M. Faddah, Maha Z. Rizk and Hisham El-Ebiary, 2007. Role of Anserine and/or Zinc in Modulating Nucleic Acid and Protein Disorders in Rats Exposed to Gamma Irradiation. Journal of Pharmacology and Toxicology, 2: 1-19.

DOI: 10.3923/jpt.2007.1.19

URL: https://scialert.net/abstract/?doi=jpt.2007.1.19

 
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