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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 6 | Page No.: 591-596
DOI: 10.3923/jpt.2006.591.596
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Anti-diarrhoea Effect of Boswellia dalzielii Stem Bark Extract in Albino Rats

E.U. Etuk, B.M. Agaie, P.A. Onyeyili and C.U. Ottah

This study examines the effect of aqueous extract of Boswellia dalzielii stem bark on castor oil induced diarrhoea in albino rats. Graded doses of the extract (100, 200 and 300 mg kg-1) were administered orally to three groups of rats (n = 6) before induction of diarrhoea with castor oil. Another two groups of the animals were treated with normal saline (control) and diphenoxylate, a conventional anti-diarrhoea drug respectively. In a separate experiment, an isolated ileum of rabbit was mounted in an organ bath containing aerated Tyrode solution. The tissue was stimulated with acetylcholine (2 μg) and its responses recorded. Various concentrations of the extract (2, 5, 10 and 20 μg) were applied to the tissue and the responses recorded. The responses were similarly recorded when acetylcholine was separately combined with atropine and 10 μg of the extract. The extract produced a significant inhibition of the castor oil induced diarrhoea in the animals in a dose dependent manner. Furthermore, the extract relaxed isolated rabbit ileum and reduced the contractions induced by acetylcholine in a manner similar to atropine during the in vitro studies. These findings suggest that, aqueous stem bark extract of Boswellia dalzielii possesses anti-diarrhoea effect, which may be related to anticholinergic mechanisms.
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How to cite this article:

E.U. Etuk, B.M. Agaie, P.A. Onyeyili and C.U. Ottah, 2006. Anti-diarrhoea Effect of Boswellia dalzielii Stem Bark Extract in Albino Rats. Journal of Pharmacology and Toxicology, 1: 591-596.

DOI: 10.3923/jpt.2006.591.596






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