Subscribe Now Subscribe Today
Science Alert
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 6 | Page No.: 579-584
DOI: 10.3923/jpt.2006.579.584
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Aluminium Acetate Induced Oxidative Stress in Brain of Albino Mice

N. John Sushma, U. Sivaiah, N. John Suraj and K. Jayantha Rao

Recently, aluminium (Al) has been identified as one of the environmental factors responsible to cause certain neurodegenerative diseases, particularly Alzheimer`s Disease (AD). However, the relationship between Al and AD is controversial. We examined aluminium induced oxidative stress in the brain of mice when aluminium acetate was administered. Albino mice were divided into four groups containing 10 animals each. The first group of animals were treated as controls and administered distilled water, to the second group of animals single dose of aluminium acetate (3.5 mg kg-1 body weight) was given. To the third group of animals double doses (7 mg kg-1 body weight) were given with 72 h interval. To the 4th group of animals multiple doses (14 mg kg-1 body weight) with 72 h interval were given. Exposure to sublethal dose (3.5 mg kg-1) of aluminium acetate has revealed significant variations in detoxification enzymes like xanthine oxidase (XOD), superoxide dismutase (SOD), catalase (CAT) and Lipid Peroxidation (LP) in different regions of brain (cerebral cortex, cerebellum, striatum, medulla) of albino mice. Present results revealed that aluminium acetate exposure increased the activities of XOD, SOD, CAT and LP in all the brain regions in a dose dependent manner, so that it induced the oxidative stress in brain of albino mice.
PDF Fulltext XML References Citation Report Citation
  •    Therapeutic Effect of Bacopa monniera Against Aluminum Induced toxicity in Medulla Oblongata of Albino rat
  •    Some Histological Observations and Microstructural Changes in the Nissl Substances in the Cerebellar Cortex of Adult Wistar Rats following Artesunate Administration
  •    Lipid Peroxidation and Antioxidant Status of the Cerebrum, Cerebellum and Brain Stem Following Dietary Monosodium Glutamate Administration in Mice
  •    Inhibitory Effect of Sulforaphane against Benzo(a)pyrene Induced Lung Cancer by Modulation of Biochemical Signatures in Female Swiss Albino Mice
How to cite this article:

N. John Sushma, U. Sivaiah, N. John Suraj and K. Jayantha Rao, 2006. Aluminium Acetate Induced Oxidative Stress in Brain of Albino Mice. Journal of Pharmacology and Toxicology, 1: 579-584.

DOI: 10.3923/jpt.2006.579.584






Curve Bottom