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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 6 | Page No.: 493-504
DOI: 10.3923/jpt.2006.493.504
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Modulation of Visceral Nociception by Capsaicin in Mice

Omar M.E. Abdel-Salam

Capsaicin administered intraperitoneally (i.p.) at increasing concentrations of 3.3 nM-0.33 mM (0.02 μg-2 mg kg-1, 0.5 mL) caused dose-dependent inhibition of abdominal constrictions induced 30 min later by i.p. acetic acid injection in mice by 53.1-86.3%. Given i.p., 1h beforehand at 0.03 mM-0.1 mM (0.4-1.2 mg kg-1, 1 mL), capsaicin inhibited the nociceptive response to acetic acid by 94.1-97.2%. Capsaicin administered p.o. (3.3, 33 μM or 0.33 mM; 20 μg kg-1, 200 μg kg-1 or 2 mg kg-1, 0.5 mL) up to 90 min before i.p. acetic acid, inhibited the abdominal constrictions by 36.8-52.7%. The antinociceptive effect of orally administered capsaicin (3.3 μM; 20 μg kg-1) was increased by co-treatment with prazosin, yohimbine, guanethidine, propranolol or atropine. Lidocaine given orally 5 min prior to capsaicin did not affect the inhibition of the abodominal constrictions by capsaicin, but lidocaine given 15 min before oral introduction of capsaicin (3.3 or 33 μM) enhanced the capsaicin-induced inhibition of the nociceptive response to acetic acid. The capsaicin antinociception was unaffected by i.p. administration of the mast cell stabilizer sodium cromoglycate or by the somatostatin depletor cysteamine. It is suggested that stimulation of capsaicin sensitive sensory afferents and transmission of nociceptive information centrally leads to the activation of descending antinociceptive mechanism to a noxious stimulus.
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How to cite this article:

Omar M.E. Abdel-Salam , 2006. Modulation of Visceral Nociception by Capsaicin in Mice. Journal of Pharmacology and Toxicology, 1: 493-504.

DOI: 10.3923/jpt.2006.493.504






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