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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 5 | Page No.: 478-484
DOI: 10.3923/jpt.2006.478.484
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Protective Effects of Some Tropical Vegetables against CCl4 Induced Hepatic Damage

S.O. Salawu and A.A. Akindahunsi

In the present study, ethanolic extracts of some tropical vegetables were investigated for their hepatoprotective effect against CCl4 induced liver damage in rats. Carbon tetrachloride at a dose of 0.5 mL kg-1 body weight (b.w) produced liver damage in rats as manifested by the rise in the levels of ALT (IU L-1), AST (IU L-1) and total protein (g L-1) in the serum (40.60±3.50, 80.60±5.10, 73.20±1.87) and in the liver homogenate (1300.00±7.38, 1660.00±13.69, 250.00±7.51) compared to the control. The extracts at a dose of 250 and 500 mg kg-1 bw were administered to the CCl4 treated rats. The vegetables produced a significant hepatoprotective effect by decreasing the serum levels of ALT, AST and total protein in the range of 11.21±1.90-16.22±1.00, 29.00±2.70-48.00±2.10, 62.10±2.40-70.13±2.00 at a dose of 250 mg kg-1 and 13.00±1.20-21.00±1.30, 40.00.±2.5-59.00±2.20, 68.00±2.40-72.00±2.10 at a dose of 500 mg kg-1. Similar results were obtained for liver homogenate levels of ALT, AST and total protein with a decreasing values compared to the control; 900.00±3.05-1020.00±4.25, 1150.00±5.57-1530.00±4.99, 150.00±3.12-185.00±3.00 and 900.00±3.05-1030.00±8.80, 1400.00±6.95-1530.00±8.50, 165.00±5.50-210.00±4.41 at a dose of 250 and 500 mg kg-1 b.w respectively. Furthermore, the effect of the extracts on lipid peroxidation, measured as Malondialdehyde (MDA) was estimated on the liver homogenate. A significant hepatoprotective effect was also noticed with a decreased value of the MDA levels: 46.00±0.08-52.00±0.06 and 47.00±0.07-60.00±0.10 at a dose of 250 and 500 mg kg-1 bw respectively. It can be concluded that all the evaluated vegetables exhibit good hepatoprotective activities, though at varying degrees.
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  •    Prostate Specific Antigen, Antioxidant and Hematological Parameters in Prostatic Rats Fed Solanum macrocarpon L. Leaves
  •    Phytonutrients and Nutraceuticals in Vegetables and Their Multi-dimensional Medicinal and Health Benefits for Humans and Their Companion Animals: A Review
How to cite this article:

S.O. Salawu and A.A. Akindahunsi , 2006. Protective Effects of Some Tropical Vegetables against CCl4 Induced Hepatic Damage. Journal of Pharmacology and Toxicology, 1: 478-484.

DOI: 10.3923/jpt.2006.478.484






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