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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 5 | Page No.: 471-477
DOI: 10.3923/jpt.2006.471.477
 
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Neuropsychobehavioral Effects and Anticancer Activity of Some Substituted Triazolo[4,3-a][1,4]Benzodiazepines

K.K. Vijaya Raj, B. Narayana , N. Suchetha Kumari , B.V.Ashalatha and B.K. Sarojini

Abstract:
Neuropsychobehavioral effects and anticancer screening of some 8-chloro-6-(2-fluorophenyl)-1-(aryl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines (3a-f) are discussed. The compounds were evaluated for antianxiety properties, effects on coordination and effects on learning and memory. The compounds were also screened for their anticancer activity. All the compounds possessed variable antianxiety properties and three of them possessed skeletal muscle relaxant property. One of the compound exhibited promising anticancer activity.
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How to cite this article:

K.K. Vijaya Raj, B. Narayana , N. Suchetha Kumari , B.V.Ashalatha and B.K. Sarojini , 2006. Neuropsychobehavioral Effects and Anticancer Activity of Some Substituted Triazolo[4,3-a][1,4]Benzodiazepines. Journal of Pharmacology and Toxicology, 1: 471-477.

DOI: 10.3923/jpt.2006.471.477

URL: https://scialert.net/abstract/?doi=jpt.2006.471.477

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