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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 4 | Page No.: 383-388
DOI: 10.3923/jpt.2006.383.388
 
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Effects of Quinine and Fansidar and Their Combination on Bovans-Type Chicks

Warda S. Abdel Gadir, Mohy Edeen, D. Abu Alazaim, Amel O. Bakhiet and I.M.T. Fadlalla

Abstract:
This study was done on 40 Bovans-type chicks to investigate the possible toxic effects of the therapeutic doses of the antimalarial drugs, Quinine and Fansidar and their combined doses. After two weeks (adaptation period), the drugs were dissolved in distilled water in concentrations of 4.33 mg mL day-1 for Quinine, 4.19 mg mL day-1 for Fansidar and their mixture (4.33 mg Quinine plus 4.19 mg Fansidar) mL day-1 and given orally to Bovans chicks for two weeks. The effects on growth and tissues were investigated. After one week, there was no change in growth and at post-mortem examination, there was congestion of liver in all tested chicks and haemorrhage on the heart of chicks that had been given Fansidar. Serobiochemical changes were increase in the activities of AST, ALT and in concentration of albumin, uric acid, total protein and globulin and decrease in cholesterol levels. There were decreases in haemoglobin, PCV, MCV and MCH values. At the end of two weeks, there was depression in growth of tested chicks, degeneration of the liver of chicks that had been given Quinine and mixture of Quinine plus Fansidar and cardiac haemorrhage in chicks that had been given fansidar and or quinine plus fansidar with increases in AST, ALT activities and in total protein concentration with decreases in globulin levels and PCV values.
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How to cite this article:

Warda S. Abdel Gadir, Mohy Edeen, D. Abu Alazaim, Amel O. Bakhiet and I.M.T. Fadlalla, 2006. Effects of Quinine and Fansidar and Their Combination on Bovans-Type Chicks. Journal of Pharmacology and Toxicology, 1: 383-388.

DOI: 10.3923/jpt.2006.383.388

URL: https://scialert.net/abstract/?doi=jpt.2006.383.388

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