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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 4 | Page No.: 337-345
DOI: 10.3923/jpt.2006.337.345
Antinociceptive and Anti-inflammatory Properties of Melastoma malabathricum Leaves Chloroform Extract in Experimental Animals
Z.A. Zakaria, R.N.S. Raden Mohd Nor, M.R. Sulaiman, Z.D.F. Abdul Ghani, G. Hanan Kumar and C.A. Fatimah

Abstract:
The present study was carried out to establish the antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves chloroform extract in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while the anti-inflammatory was measured using the carrageenan-induced paw edema. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by evaporation under vacuo (40°C) to dryness (4.38 g), was dissolved in dimethyl sulfoxide to the doses of 20, 100 and 200% and administered subcutaneously 30 min prior to subjection to the above mentioned assays. The extract, at all concentration used, was found to exhibit significant (p<0.05) antinociceptive and anti-inflammatory activities. Only the effect observed with the formalin test occurred in a concentration-dependent manner. It is concluded that the lipid-soluble compounds within the chloroform extract of M. malabathricum leaves possess potential antinociceptive and anti-inflammatory agents that require further attention.
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How to cite this article:

Z.A. Zakaria, R.N.S. Raden Mohd Nor, M.R. Sulaiman, Z.D.F. Abdul Ghani, G. Hanan Kumar and C.A. Fatimah, 2006. Antinociceptive and Anti-inflammatory Properties of Melastoma malabathricum Leaves Chloroform Extract in Experimental Animals. Journal of Pharmacology and Toxicology, 1: 337-345.

DOI: 10.3923/jpt.2006.337.345

URL: https://scialert.net/abstract/?doi=jpt.2006.337.345

 
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