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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 3 | Page No.: 293-298
DOI: 10.3923/jpt.2006.293.298
 
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Effects of Intracerebroventricular Administration of 2-Chloroadenosine in Genetically Absence Epileptic WAG/Rij Rats

Gul Ilbay, Deniz Sahin and Nurbay Ates

Abstract:
The effects of intracerebroventricular (icv) application of 2-chloroadenosine (CADO), a non-selective analogue of adenosine receptor were determined at different time intervals in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rat strain, a genetic model of absence epilepsy. After an hour of baseline recording, either CADO or saline injection were made icv and then, an hour electroencephalogram (EEG) epoch were recorded at 1st, 24th, 48th and 72nd h. Then, the number and total duration of spike-wave discharges (SWD) were established. Spontaneous behaviours of animals before and after drug administration were also observed during the recording periods. Both the number and the total duration of SWD increased following administration of CADO. Statistical analysis revealed that during the post injection hours, CADO induced a significant increment both in the number and total duration of SWD compared with the control group. This study demonstrates that activation of central adenosine receptors lead to long term provocation of seizure activity in generalized absence epilepsy.
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How to cite this article:

Gul Ilbay, Deniz Sahin and Nurbay Ates , 2006. Effects of Intracerebroventricular Administration of 2-Chloroadenosine in Genetically Absence Epileptic WAG/Rij Rats. Journal of Pharmacology and Toxicology, 1: 293-298.

DOI: 10.3923/jpt.2006.293.298

URL: https://scialert.net/abstract/?doi=jpt.2006.293.298

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