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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 3 | Page No.: 270-277
DOI: 10.3923/jpt.2006.270.277
 
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Influence of Calcium and Zinc on Lead-induced Alterations in ATPases in the Developing Mouse Brain

R.P. Jaya Prasanthi, G. Hariprasad Reddy , C.S. Chetty and G. Rajarami Reddy

Abstract:
Developing nervous system has long been recognized as a primary target for lead (Pb2+) induced toxicity. We have examined the effect of calcium (Ca2+) and zinc (Zn2+) supplementation on Pb2+-induced alterations in adenosine triphosphatase (ATPase) activities in the developing mouse brain from postnatal day (PND) 14 to 90. Albino mice were lactationally exposed to low (0.2%) and high (1%) levels of lead acetate via the drinking water of the mother. Pb2+-exposure was commenced on PND 1, continued up to PND 21 and stopped at weaning. Ca2+ and Zn2+ (0.02% in 0.2% Pb2+-water or 0.1% in 1% Pb2+-water) were supplemented separately to the mother up to PND 21. The activities of Mg2+ATPase in mitochondrial fraction and Na+K+ATPase in P2-fraction of the cerebral cortex, hippocampus, cerebellum and medulla were assayed. The specific activity of both ATPases increased gradually in an age-dependent manner in the control brain. Pb2+-exposure significantly inhibited the activities of both Mg2+ATPase and Na+K+ATPase in different brain regions of the developing brain. The inhibition was more pronounced at PND 28 in the brain regions of mice exposed to 1% Pb2+. Ca2+ or Zn2+-supplementation significantly reversed the Pb2+-inhibited activity of both ATPases. These results indicate that dietary Ca2+/Zn2+-supplementation decreases intestinal absorption of Pb2+ and there by reduces the neurotoxic effects of Pb2+.
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How to cite this article:

R.P. Jaya Prasanthi, G. Hariprasad Reddy , C.S. Chetty and G. Rajarami Reddy , 2006. Influence of Calcium and Zinc on Lead-induced Alterations in ATPases in the Developing Mouse Brain. Journal of Pharmacology and Toxicology, 1: 270-277.

DOI: 10.3923/jpt.2006.270.277

URL: https://scialert.net/abstract/?doi=jpt.2006.270.277

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