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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 2 | Page No.: 108-114
DOI: 10.3923/jpt.2006.108.114
 
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The in vitro Antibacterial Activity of Corchorus olitoriusand Muntingia calabura Extracts

Z.A. Zakaria, H. Zaiton, E.F.P. Henie, A.M. Mat Jais, D. Kasthuri, M. Thenamutha, F.W. Othman, R. Nazaratulmawarina and C.A. Fatimah

Abstract:
The present study was carried out to evaluate the possible antibacterial activity of aqueous (AEMC), methanol (MEMC) and chloroform (CEMC) extracts of Muntingia calabura as well as methanol (MECO) and chloroform (CECO) extracts of Corchorus olitorius using the in vitro disc diffusion methods. The sterilized blank discs (6 mm diameter) was impregnated with 20 μL of the respective extract (the concentrations were 10,000, 20,000, 40,000 and 50,000 ppm for C. olitorius and 10,000, 40,000, 70,000 and 100,000 ppm for M. calabura) and tested against Salmonella enteriditis, Citrobacter fruendii, Enterobacter aerogenes, Klebsiella pneumoniae, Vibrio cholerae, Vibrio parahemolyticus, Pseudomonas aeruginosa and Salmonella typhi. The AEMC was effective in inhibiting the growth of all bacteria at the concentration of 70,000 ppm; the MEMC was effective in inhibiting the growth of C. fruendii, K. pneumoniae, V. cholerae, V. parahemolyticus and S. typhi; and the CEMC was ineffective at all concentrations tested. However, the MECO and CECO were ineffective against all bacteria tested. Except for P. aeruginosa, the standard antibiotic chloramphenicol (30 μg μL-1) was found to give inhibition zone of more than 20 mm against all bacteria tested. Based on this study, we concluded that M. calabura, but not C. olitorius, possesses a potential antibacterial activity against the selected microorganisms and this may provide a basis for the isolation of compounds of biological interest from M. calabura.
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How to cite this article:

Z.A. Zakaria, H. Zaiton, E.F.P. Henie, A.M. Mat Jais, D. Kasthuri, M. Thenamutha, F.W. Othman, R. Nazaratulmawarina and C.A. Fatimah, 2006. The in vitro Antibacterial Activity of Corchorus olitoriusand Muntingia calabura Extracts. Journal of Pharmacology and Toxicology, 1: 108-114.

DOI: 10.3923/jpt.2006.108.114

URL: https://scialert.net/abstract/?doi=jpt.2006.108.114

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