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Journal of Pharmacology and Toxicology

Year: 2006 | Volume: 1 | Issue: 2 | Page No.: 101-107
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Authors

Ajay Kumar Gupta

Havagiray Chitme

Sujata K. Dass

Neelam Misra

Keywords

Research Article

Antioxidant Activity of Chamomile recutita Capitula Methanolic Extracts against CCl4-Induced Liver Injury in Rats

Ajay Kumar Gupta, Havagiray Chitme, Sujata K. Dass and Neelam Misra
Antioxidant activity of Methanolic Extract (MET) of capitula of Chamomile recutita was investigated in rats by inducing liver injury with CCl4. The MET exhibited significant antioxidant activity by showing increased levels of Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), Glutathione Reductase (GRD), Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione (GSH). The decreased level of Lipid Peroxidation (LPO) has also been shown. The MET, at a dose level of 300 mg kg -1 showed significant antioxidant activity against CCl4 induced liver injury in rats. MET of C. recutita had been shown a potent and prominent free radical scavenging activity and CCl4-intoxicated liver recovery towards normalcy in the methanol extract co-administered rats revealed the effectiveness of C. recutita in combating oxidation stress due to hepatic damage. Thus, the MET possess antioxidant activities with combined hepatoprotective action has a synergistic effect to stabilize cellular membrane or antiperoxidase activity.
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