Antioxidant Activity of Chamomile recutita Capitula Methanolic Extracts against CCl4-Induced Liver Injury in Rats


	Journal of Pharmacology and Toxicology
	Year: 2006 \| Volume: 1 \| Issue: 2 \| Page No.: 101-107 DOI: 10.3923/jpt.2006.101.107

Antioxidant Activity of Chamomile recutita Capitula Methanolic Extracts against CCl₄-Induced Liver Injury in Rats

Ajay Kumar Gupta, Havagiray Chitme, Sujata K. Dass and Neelam Misra

Abstract: Antioxidant activity of Methanolic Extract (MET) of capitula of Chamomile recutita was investigated in rats by inducing liver injury with CCl₄. The MET exhibited significant antioxidant activity by showing increased levels of Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), Glutathione Reductase (GRD), Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione (GSH). The decreased level of Lipid Peroxidation (LPO) has also been shown. The MET, at a dose level of 300 mg kg ^-1 showed significant antioxidant activity against CCl₄induced liver injury in rats. MET of C. recutita had been shown a potent and prominent free radical scavenging activity and CCl₄-intoxicated liver recovery towards normalcy in the methanol extract co-administered rats revealed the effectiveness of C. recutita in combating oxidation stress due to hepatic damage. Thus, the MET possess antioxidant activities with combined hepatoprotective action has a synergistic effect to stabilize cellular membrane or antiperoxidase activity.

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How to cite this article:

Ajay Kumar Gupta, Havagiray Chitme, Sujata K. Dass and Neelam Misra, 2006. Antioxidant Activity of Chamomile recutita Capitula Methanolic Extracts against CCl₄-Induced Liver Injury in Rats. Journal of Pharmacology and Toxicology, 1: 101-107.

DOI: 10.3923/jpt.2006.101.107

URL: https://scialert.net/abstract/?doi=jpt.2006.101.107

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