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Journal of Pharmacology and Toxicology
  Year: 2006 | Volume: 1 | Issue: 2 | Page No.: 101-107
DOI: 10.3923/jpt.2006.101.107
Antioxidant Activity of Chamomile recutita Capitula Methanolic Extracts against CCl4-Induced Liver Injury in Rats
Ajay Kumar Gupta, Havagiray Chitme, Sujata K. Dass and Neelam Misra

Abstract:
Antioxidant activity of Methanolic Extract (MET) of capitula of Chamomile recutita was investigated in rats by inducing liver injury with CCl4. The MET exhibited significant antioxidant activity by showing increased levels of Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), Glutathione Reductase (GRD), Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione (GSH). The decreased level of Lipid Peroxidation (LPO) has also been shown. The MET, at a dose level of 300 mg kg -1 showed significant antioxidant activity against CCl4 induced liver injury in rats. MET of C. recutita had been shown a potent and prominent free radical scavenging activity and CCl4-intoxicated liver recovery towards normalcy in the methanol extract co-administered rats revealed the effectiveness of C. recutita in combating oxidation stress due to hepatic damage. Thus, the MET possess antioxidant activities with combined hepatoprotective action has a synergistic effect to stabilize cellular membrane or antiperoxidase activity.
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How to cite this article:

Ajay Kumar Gupta, Havagiray Chitme, Sujata K. Dass and Neelam Misra, 2006. Antioxidant Activity of Chamomile recutita Capitula Methanolic Extracts against CCl4-Induced Liver Injury in Rats. Journal of Pharmacology and Toxicology, 1: 101-107.

DOI: 10.3923/jpt.2006.101.107

URL: https://scialert.net/abstract/?doi=jpt.2006.101.107

 
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