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Journal of Plant Sciences
  Year: 2007 | Volume: 2 | Issue: 4 | Page No.: 447-452
DOI: 10.3923/jps.2007.447.452
Antiinflammatory Activity of Ethanolic Leaf Extract from Carica papaya in Rats Orogastrically Dosed with Salmonella typhi and Staphylococcus aureus
M.K. Oladunmoye and I.B. Osho

Abstract:
The anti-inflammatory activity of ethanolic extract of Carica papaya was investigated in Swiss Albino rats with induced multiple infections from Staphylococcus aureus and Salmonella typhi. The first group was given the standard inoculums of Staphylococcus aureus only while the second group was given the standard inoculum=s of S. aureus and treated with ethanol extract of Carica papaya. The rats in the third group were given standard inoculums of Salmonella typhi only and those in the fourth category were given standard inoculums of S. typhi and treated with the extract. The Albino rat in the last group was placed on basal diet and water only to serve as the control. The anti-inflammatory activity of the extract as haematological indices was determined by monitoring the amount, occurrence and distributions of total and differential White Blood Count (WBC), haemoglobin level and Pack Cell Volume count (PCV) before and after infection with the pathogenic bacteria. The rats infected with Staphylococcus aureus without extract treatment gave a PCV value of 33%, a WBC of 3650 mm3, an Hb value of 2.2H1012 LG1, a neutrophil count of 60%, lymphocyte 40% and monocytes of 1%. The rats infected with Staphylococcus aureus and treated with C. papaya showed an increase in PCV count of 36%, the WBC increase to 4050 mm3, an Hb count 2.4H1012 LG1 and increase in neutrophil to 74% and reduction in lymphocyte to 24% while the monocytes count was 2%. The rats infected with S. typhi only gave a PCV count of 24%, WBC 2050 mm3, a RBC 1.0H1012 LG1, a neutrophil value of 60%, lymphocyte 38% and monocytes count of 2%. The rats infected with S. typhi and treated showed an increase in PCV value to 38%, reduction in WBC to 4275 mm3, an Hb count of 1.9H1012 LG1, neutrophil 67%, a lymphocyte count of 30% and Eosiniphils 1%. The control group gave values that were within the acceptable limit. The urinalysis showed that the rats infected with Staphylococcus aureus only had a pH of 6, negative to glucose and nitrite, positive to ascorbic acid, ketone, bilirubin, blood (Ca250) and normal urobilinogen with 100 mg mLG1 of protein. The group infected with Staphylococcus aureus and treated with the extract showed an increase in pH to 7, negative to glucose, ascorbic acid, ketoses and nitrite, 30 mg mLG1 of protein, bilirubin, blood (Ca50) and urobilinogen were in the normal range. The animals infected with Salmonella typhi only showed a pH of 6, negative to glucose, bilirubin and blood (Ca50) and permissible level of urobilinogen. The rats infected with Salmonella typhi and treated with the extract showed reduction in pH to 5, negative to glucose, ketone, nitrite and blood, positive to ascorbic acid, protein, bilirubin and normal urobilinogen. The values of all the urinary compositions were normal except blood (Ca250) for the control. The results obtained justify the scientific bases for the use of the plant in ethnomedicine.
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How to cite this article:

M.K. Oladunmoye and I.B. Osho, 2007. Antiinflammatory Activity of Ethanolic Leaf Extract from Carica papaya in Rats Orogastrically Dosed with Salmonella typhi and Staphylococcus aureus . Journal of Plant Sciences, 2: 447-452.

DOI: 10.3923/jps.2007.447.452

URL: https://scialert.net/abstract/?doi=jps.2007.447.452

 
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