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Journal of Pharmacy and Allied Health Sciences
  Year: 2012 | Volume: 2 | Issue: 2 | Page No.: 21-39
DOI: 10.3923/jpahs.2012.21.39
Recent Advances in Novel Drug Delivery System Through Gels: Review
N. Bhoyar, T.K. Giri, D.K. Tripathi, A. Alexander and Ajazuddin

Abstract:
The term gel are semi-solid, three dimensional, polymeric matrices comprising small amounts of solid dispersed in relatively large amount of liquid, yet possessing more solid like character. These systems form a three-dimensional, polymeric matrix in which a high degree of physical reticulation has been comprised. They are formed of long, disordered chains that are connected at specific points, but the connections must be reversible. They are coherent colloid disperse systems at least two components. They exhibit mechanical properties characteristic of the solid state, both the dispersed component and the dispersion medium extend themselves continuously throughout the whole system. Gels are transparent or translucent semisolid formulations containing a high ratio of solvent/gelling agent. When dispersed in an appropriate solvent, gelling agents merge or entangle to form a three-dimensional colloidal network structure, which limits fluid flow by entrapment and immobilization of the solvent molecules. The network structure is also responsible for gel resistance to deformation and hence, its viscoelastic properties. Topical gel formulation provides a suitable delivery system for drugs because they are less greasy and can be easily removed from the skin. Gel formulation provide better application property and stability in comparison to cream and ointments. In this study example, method and structure of gel are discussed to improve the permeability and bioavailability of gels that can be incorporate in to a novel drug delivery system like solid dispersion into gel, emulgel, hydrogel, in situ gel, solid lipid nanoparticles into gel and microemulsion gel.
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How to cite this article:

N. Bhoyar, T.K. Giri, D.K. Tripathi, A. Alexander and Ajazuddin , 2012. Recent Advances in Novel Drug Delivery System Through Gels: Review. Journal of Pharmacy and Allied Health Sciences, 2: 21-39.

DOI: 10.3923/jpahs.2012.21.39

URL: https://scialert.net/abstract/?doi=jpahs.2012.21.39

 
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