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Journal of Pharmacy and Allied Health Sciences

Year: 2011 | Volume: 1 | Issue: 1 | Page No.: 16-29
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Authors

Veena Sharma

Leena Kansal

Arti Sharma

Shweta Lodi

S.H. Sharma

Keywords

Research Article

Ameliorating Effect of Coriandrum sativum Extracts on Hematological and Immunological Variables in an Animal Model of Lead Intoxication

Veena Sharma, Leena Kansal, Arti Sharma, Shweta Lodi and S.H. Sharma
To study the efficacy of Coriandrum sativum as an antioxidant in lead intoxicated mice. Oxidative stress was induced in mice by a daily dose of lead nitrate (40 mg kg-1 body weight by oral gavage) for seven days. From day eight, experimental animals received an oral dose of coriander extracts (aqueous extract -300 and 600 mg kg-1 body weight; ethanolic extract -250 and 500 mg kg-1 body weight) along with lead nitrate daily for 40 days. The coriander supplementation to intoxicated mice has protected the weights of experimental animals as compared to lead nitrate exposed animals. Ingestion of Pb (NO3)2 was significantly decreased RBC count, WBC count, Hb level and serum total protein contents in the lead nitrate treated mice. But, serum alanine transaminase, aspartate aminotransferase, creatinine and cholesterol level were significantly increased after implication of this metal. However, oral administration of Coriandrum sativum to lead treated mice led to marked improvement in both hematological and serum biochemical changes. A decrease in viability of neutrophiles, phagocytic index, immunoglobulin level and plaque count were the salient features observed in lead exposed animals. Oral administration of coriander extracts to Pb (NO3)2 treated groups attenuated the deranged parameters to some extent. The study reveals that treatment with coriander significantly protect against lead induced toxicity and warrants the isolation and identification of active compounds responsible for its antioxidant effect.
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How to cite this article

Veena Sharma, Leena Kansal, Arti Sharma, Shweta Lodi and S.H. Sharma, 2011. Ameliorating Effect of Coriandrum sativum Extracts on Hematological and Immunological Variables in an Animal Model of Lead Intoxication. Journal of Pharmacy and Allied Health Sciences, 1: 16-29.

DOI: 10.3923/jpahs.2011.16.29

URL: https://scialert.net/abstract/?doi=jpahs.2011.16.29

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