• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Research Journal of Parasitology
  2. Vol 6 (5), 2011
  3. 151-159
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Research Journal of Parasitology

Year: 2011 | Volume: 6 | Issue: 5 | Page No.: 151-159

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 515

Search


Authors


A.F. El-kott

Country: Egypt

R.T. Mohammed

Country: Egypt

N.R. Ismail

Country: Egypt

Keywords


  • Commiphora molmol
  • Schistosoma mansoni
  • granuloma
  • garlic
  • mirazid
Research Article

Efficacy of Garlic and Mirazid in Treatment of the Liver Granuloma in Mice Infected with Schistosoma mansoni

A.F. El-kott, R.T. Mohammed and N.R. Ismail
This study has investigated the potency of traditional medicinal plants such as Allium sativum (garlic) and Commiphora molmol derivative (Mirazid) for treating schistosomiasis and the liver granuloma formation. The effects of garlic and mirazid on Schistosoma mansoni infected mice were examined by liver enzymes, counting worm burden, schistosome egg load, modulation of the granuloma and histopathology of the liver injury. The use of garlic or mirazid or combination of them led to marked reduction in worm load (43, 52 and 70%, respectively), ova deposition (43, 59 and 83%, respectively), size and number of granuloma (38, 46 and 67%, respectively) in the liver of mice infected with schistosoma. Also, these treatments ameliorated the histopathological injury changes of the liver and physiological assays of AST, ALT and total bilirubin. These findings indicate that garlic, mirazid and a combination of them have anti-schistosomal activity in mice. All of them significantly reduced the production of eggs output in S. mansoni infected mice. In addition, garlic and mirazid combination clearly reduced the liver granuloma size which was reflected by the degree of improvement in the status of the liver. To our knowledge, this study is the first in using the combination of garlic and mirazid in schistosomal treatment in mice.
PDF Fulltext XML References Citation

How to cite this article

A.F. El-kott, R.T. Mohammed and N.R. Ismail, 2011. Efficacy of Garlic and Mirazid in Treatment of the Liver Granuloma in Mice Infected with Schistosoma mansoni. Research Journal of Parasitology, 6: 151-159.

URL: https://scialert.net/abstract/?doi=jp.2011.151.159

Related Articles

Susceptibility of Hedgehog, Hemiechinus auritus to Schistosoma mansoni under Experimental Infection
Parasitological Changes Within Experimentally Murine Schistosomiasis Mansoni upon Treatment by Somatostatin, Artemether and Their Combination

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved