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Research Journal of Parasitology
  Year: 2011 | Volume: 6 | Issue: 1 | Page No.: 1-17
DOI: 10.3923/jp.2011.1.17
 
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Advances in Amoebiasis Research Emphasizing Immunological and Oxidative Aspects
A.C. Franca-Botelho, R.P. Lopes, J.L. Franca and M.A. Gomes

Abstract:
The purpose of this review is to report the scientific advances of amoebiasis, especially focusing the innate immune response and the oxidative stress related to the infection. Amoebiasis is a significant cause of morbidity and mortality, affects about 50 million persons and leads to approximately 100.000 deaths worldwide each year. As to the virulence, the different strains of Entamoeba histolytica and Entamoeba dispar can be characterized in several forms. The main ones are: the capacity of inducing liver abscess in hamsters, the erythrophagocytosis and the cytopathic effect on VERO cells. The tissue invasion by E. histolytica trophozoites induces a humoral immune response, which may persist for several years, being verified by the levels of antibodies. However, it is the cellular immune response that has been described as the most effective one. It still remains unclear whether, the oxidative stress generated at the inflammatory sites of amoebiasis gives rise to benefits or injuries to the host, or if both possibilities may coexist, depending on other factors such as, for instance, the type of strain and the profile of the host immune response. A better understanding on the relationship between parasite and the host immune response is crucial for the development of vaccines and for the improvement of therapeutic alternatives to amoebiasis.
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How to cite this article:

A.C. Franca-Botelho, R.P. Lopes, J.L. Franca and M.A. Gomes, 2011. Advances in Amoebiasis Research Emphasizing Immunological and Oxidative Aspects. Research Journal of Parasitology, 6: 1-17.

DOI: 10.3923/jp.2011.1.17

URL: https://scialert.net/abstract/?doi=jp.2011.1.17

COMMENTS
29 April, 2012
farhan abood:
i need modern studies about protozoan parasites
 
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