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Research Journal of Parasitology
  Year: 2008 | Volume: 3 | Issue: 2 | Page No.: 32-39
DOI: 10.3923/jp.2008.32.39
 
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Therapeutic Efficacy of Chloroquine for Uncomplicated Plasmodium falciparum Malaria in Nigerian Children at the Time of Transition to Artemisinin-Based Combination Therapy

R.A. Umar, S.W. Hassan, M.J. Ladan, M. Nma Jiya, I.K. Matazu, M.K. Abubakar, U. Nata`ala and K. Abdullahi

Abstract:
In a prospective cross sectional study, the therapeutic efficacy of chloroquine was assessed in children under the age of five years with uncomplicated P. falciparum malaria in Sokoto, Nigeria, using the in vivo 14 day World Health Organization`s protocol (with some modifications). One hundred and twenty six children aged 2 to 59 months were enrolled, out of which 108 completed the study. Clinical, parasitological and haematological data at study start and end were obtained by standard methods. Children were treated with 25 mg kg-1 body weight over 3 days. Adequate clinical and parasitological response was 72.2%, clinical failure was 23.27 and total treatment failure 27.8%. Because of unacceptably high rate of treatment failures due to diminishing efficacy, chloroquine cannot remain the recommended first line drug for the treatment of P. falciparum malaria in pre-school children in Nigeria and the antimalarial treatment policy change from chloroquine to Artemisin-based combination was necessary and justified. Challenges to the success of the policy for control of malaria morbidity and mortality were discussed.
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How to cite this article:

R.A. Umar, S.W. Hassan, M.J. Ladan, M. Nma Jiya, I.K. Matazu, M.K. Abubakar, U. Nata`ala and K. Abdullahi, 2008. Therapeutic Efficacy of Chloroquine for Uncomplicated Plasmodium falciparum Malaria in Nigerian Children at the Time of Transition to Artemisinin-Based Combination Therapy. Research Journal of Parasitology, 3: 32-39.

DOI: 10.3923/jp.2008.32.39

URL: https://scialert.net/abstract/?doi=jp.2008.32.39

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