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Research Journal of Parasitology
  Year: 2008 | Volume: 3 | Issue: 1 | Page No.: 12-19
DOI: 10.3923/jp.2008.12.19
 
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Effect of Solanum lycocarpum Aqueous Extracts in Helminth Parasites of Conventionally Maintained Laboratory Mice
D.P.C. Costa, A.P.S. Cruz, L.L.F. Aguiar, J.C.S. Oliveira, G.L.T. Fernandes, S.D.D. Vasconcelos, J.S. Rodrigues, G.F. Dire and H.R. Borba

Abstract:
This approach intends to add new data on the helminthes parasites of laboratory mice. It has been investigated the anthelmintic activity of Solanum lycocarpum (Solanaceae) extracts against Vampirolepis nana and Aspiculuris tetraptera in mice naturally infected. The extracts were applied for oral saw (intragastric), into the volume of 0.04 mL g-1, with the employing of a dead and bend probe during three consecutive days. The fecal material, collected 24 h after each application, performing a total of four fecal collection, have been softened previously, transferred about to sieve of network of 125 µm and tested under microscope stereoscope, with the objective of behave the identification and counting from the worms eliminated of the second to the fifth day of the experimental. Tukey-Kramer Multiple Comparisons Test was applied to compare the results. According to the analysis of the results it was observed that there were no differences in the % of elimination to the concentration of 10% between TM and UR (from 28.4±3.55 to 29.2±2.92) and statistical differences between TM and C (from 28.4±3.55 to 15.0±1.5) and UR and C (from 29.2±2.92 to 15.0±1.5). To the concentration of was observed that there were differences in the of eliminating between TM and UR (from 30.9±3.43 to 7.7±1.1) and C (from 30.9±3.43 to 15±1.5) related to the experimental which the animal was infecting with Vampirolepis nana. To the concentration of 5% it was observed that there were no differences in the % of elimination between TM and UR (from 4.18±3.33 to 3.70±3.16), TM and C (from 4.18±3.33 to 1.56±3.16) and UR and C (from 3.70±3.16 to 1.56±3.16) related to the experimental which the animal was infected with Aspiculuris tetraptera. It was described that in the chemical analysis of the studied extract there is the presence of glycoalkaloids, a finding that represents a reason for concern since many of these substances are generally toxic and maybe anthelmintic. It was published that medicinal plants which were reported as useful in the treatment of diabetes the S. lycocarpum was the sixth most frequently mentioned. According to the results obtained in the present study, we can speculate that the anthelmintic effect of S. lycocarpum would be related to the action of steroidal alkaloid oligoglycosides as well as the presence of short-chain fatty acids as well as with the concentration of the referred compounds in the extracts.
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How to cite this article:

D.P.C. Costa, A.P.S. Cruz, L.L.F. Aguiar, J.C.S. Oliveira, G.L.T. Fernandes, S.D.D. Vasconcelos, J.S. Rodrigues, G.F. Dire and H.R. Borba, 2008. Effect of Solanum lycocarpum Aqueous Extracts in Helminth Parasites of Conventionally Maintained Laboratory Mice. Research Journal of Parasitology, 3: 12-19.

DOI: 10.3923/jp.2008.12.19

URL: https://scialert.net/abstract/?doi=jp.2008.12.19

 
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