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Journal of Medical Sciences
  Year: 2020 | Volume: 20 | Issue: 1 | Page No.: 34-38
DOI: 10.3923/jms.2020.34.38
 
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Dutasteride and Lycopene Combination for Bleeding Control in Post Transurethral Resection of Prostate Evaluated by VEGF Expression and Hemoglobin Level
Eriawan Agung Nugroho , Siti Amarwati, Ian Oscar Prima, Yanuar Hendra Wijaya and Krisna Muhammad

Abstract:
Background and Objective: Bleeding is a complication that can happen during transurethral resection of the prostate (TURP) or post surgery. Dutasteride and lycopene can reduce the rate of bleeding complication in benign prostate hyperplasia (BPH). The study aims to analyze the effect of combination of dutasteride and lycopene in decreasing the amount of bleeding in BPH patients underwent TURP. Materials and Methods: The study is an experimental double blind randomized control trial post test only. It was performed by comparing changes in angiogenesis with VEGF expression and hemoglobin levels as the parameters. The study divided the sample into 2 groups of BPH patients underwent TURP; the first group was given Dutasteride 0.5 mg once daily combined with lycopene 30 mg once daily 30 days prior to surgery and the second group was given Dutasteride 0.5 mg only. Results: Combination of dutasteride and lycopene was not significant in reducing VEGF expressions, as evidenced by the results of statistical tests with Independent t-test in 2 groups which obtained p = 0.43. Mean data of hemoglobin level in each group showed significant result with p = 0.00. Conclusion: Combination of Dutasteride and lycopene 30 days prior to TURP surgery is not significant compared to Dutasteride alone in decreasing VEGF expression, but there was a significant result in Hemoglobin level comparison between pre and post operative.
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How to cite this article:

Eriawan Agung Nugroho, Siti Amarwati, Ian Oscar Prima, Yanuar Hendra Wijaya and Krisna Muhammad, 2020. Dutasteride and Lycopene Combination for Bleeding Control in Post Transurethral Resection of Prostate Evaluated by VEGF Expression and Hemoglobin Level. Journal of Medical Sciences, 20: 34-38.

DOI: 10.3923/jms.2020.34.38

URL: https://scialert.net/abstract/?doi=jms.2020.34.38

 
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