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Journal of Medical Sciences
  Year: 2016 | Volume: 16 | Issue: 1-2 | Page No.: 38-43
DOI: 10.3923/jms.2016.38.43
 
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Male Infertility and Cytogenetic Disorders: A Cross-Sectional Study

Rahma Belmokhtar, Fayza Belmokhtar and Ahmed Kerfouf

Abstract:
Infertility is a very common health problem. In this study, the relationship between cytogenetic disorders, semen parameters and reproductive hormone levels of infertile men from Western region of Algeria, Tlemcen, was evaluated. A total of 27 infertile males were studied for the cytogenetic evaluation. Also, 12 fertile males as a control group were studied. Karyotyping was performed on peripheral blood lymphocytes according to the standard methods. Semen analysis and endocrine evaluation were carried out. The prevalence of abnormal chromosomal karyotype in the patients with abnormal sperm parameters was 11.11%. The most frequent cause was Klinefelter’s syndrome (03/27). The levels of testosterone (T) in patient group were significantly lower than those of fertile group (p<0.0001). In addition, the levels of Follicle-Stimulating Hormone (FSH) (p<0.0001), and Luteinizing Hormone (LH) (p<0.0001) were significantly higher in patients than those in the fertile group. The same results of hormone levels were found when compared the patients with normal and abnormal karyotype. Cytogenetic disorders have severe adverse of sperm concentration and reproductive hormone levels. These findings suggest the need for routine genetic testing and counseling prior to the employment of assisted reproduction techniques.
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How to cite this article:

Rahma Belmokhtar, Fayza Belmokhtar and Ahmed Kerfouf, 2016. Male Infertility and Cytogenetic Disorders: A Cross-Sectional Study. Journal of Medical Sciences, 16: 38-43.

DOI: 10.3923/jms.2016.38.43

URL: https://scialert.net/abstract/?doi=jms.2016.38.43

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