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Journal of Medical Sciences
  Year: 2015 | Volume: 15 | Issue: 1 | Page No.: 18-24
DOI: 10.3923/jms.2015.18.24
 
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Formulation and Evaluation of Tablets from Antidiabetic Alkaloid Glycosin

Gurudeeban Selvaraj, Satyavani Kaliamurthi, Ramanathan Thirugnanasambandam and Mohanraj Palanisamy

Abstract:
Mangroves derived alkaloid on medications of diabetes mellitus are insufficient. The oral route is widely preferred convenience way of drug administration. Therefore, the present study was aimed to formulate and evaluate tablet from the anti-diabetic alkaloid glycosin from Rhizophora apiculata. Powder form of glycosin (10 g) mixed with suitable active ingredient and excipients to formulate tablets by punching method. The starch, aerosol colloidal silicon dioxide, gelatin, magnesium stearate selected as diluents, disintegrant, binding agent and lubricant selected for glycosin tablet formulation. Tablets determined for mass, hardness, disintegration, friability, dissolution and stability. Each glycosin tablet contain 50 mg of the active ingredients. The weight, diameter and thickness of each glycosin tablet were 50 mg and 10 mm, the variation in thickness was 5% deviation limit. Glycosin tablets showed potential hardness (3.5-4.5 kg cm-2) which facilitates its rapid disintegration within 35.22-36.23 min. The percentage of difference in friability was 0.351% indicated that the of glycosin tablets were mechanically stable. The overall dissolution patterns of the six glycosin tablet were characterized by 50% rapid release in the first 15 min followed by 90% at 75 min. The tablet showed potential stability when stored at different storage conditions for 40 days. The formulated glycosin tablet would be great potential in the treatment of diabetes mellitus.
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How to cite this article:

Gurudeeban Selvaraj, Satyavani Kaliamurthi, Ramanathan Thirugnanasambandam and Mohanraj Palanisamy, 2015. Formulation and Evaluation of Tablets from Antidiabetic Alkaloid Glycosin. Journal of Medical Sciences, 15: 18-24.

DOI: 10.3923/jms.2015.18.24

URL: https://scialert.net/abstract/?doi=jms.2015.18.24

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