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Journal of Medical Sciences
  Year: 2015 | Volume: 15 | Issue: 2 | Page No.: 100-104
DOI: 10.3923/jms.2015.100.104
 
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Effect of Tridax procumbens Extracts on Ethanol Induced Gastric Ulceration in Wistar Rats

G.O. Obochi, J. Ikwebe, S.A. Ogli and J.J. Oloche

Abstract:
The effect of Tridax procumbens extracts on ethanol induced gastric ulceration in Wistar rats was studied. Twelve Wistar rats weighing 150-250 g were used for the study. Gastric ulceration was induced with 0.2 mL kg–1 b.wt. of the necrotizing agent (80% ethanol-in- 0.1N HCl) and were treated as follows: Group 1 (control) was treated with 0.2 mL kg–1 b.wt. of the vehicle (placebo), groups 2 and 3 were treated with 100 and 250 mg kg–1 b.wt. of the extracts, respectively and group 4 was treated with 250 mg kg–1 b.wt. of the standard drug, omeprazole. The experiments lasted for 21 days. Acute toxicity test (Median lethal dose, LD50), gastric juice pH, gastric acid concentration, gastric ulcer scores, gastric ulcer index, percentage ulcer protection (% ulcer inhibition), activity levels of superoxide dismutase (SOD), catalase and malondialdehyde (MDA) were determined. The results showed that the extracts highly statistically (p<0.05) increased the gastric juice pH ranging from 3.7±0.36 to 4.47±0.15 compared with pH value of 1.46±0.14 in the control. The percentage ulcer protection in the extract treated groups ranged between 49.5-97.6% in a dose dependent manner. Inhibition of gastric ulceration in the extract (97.6%) and omeprazole (98.7%) treated rats was similar at a dose of 250 mg kg–1. The control did not exhibit ulcer protection. Activities of superoxide dismutase (SOD) were 87.4±2.44 and 91.53±1.53 μmol mg–1 at doses of 100 and 250 mg kg–1 of extract, respectively. There was no statistical difference (p>0.05) between SOD of the extracts (91.53±1.43 μmol mg–1) and omeprazole (92.03±1.44 μmol mg–1) both at a dose of 250 mg kg–1. Malondialdehyde (MDA) was 43.6±0.66 and 33.73±1.17 μmol mg–1 in the extracts and 42.63±2.14 μmol mg–1 in omeprazole treated rats. The distilled water treated rats had MDA of 66.87±2.14 μmol mg–1. The results of the study therefore, suggest that Tridax procumbens extracts possess anti-ulcerogenic and antioxidant properties against 80% ethanol-in-0.1N HCl induced gastric ulceration in Wistar rats.
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How to cite this article:

G.O. Obochi, J. Ikwebe, S.A. Ogli and J.J. Oloche, 2015. Effect of Tridax procumbens Extracts on Ethanol Induced Gastric Ulceration in Wistar Rats. Journal of Medical Sciences, 15: 100-104.

DOI: 10.3923/jms.2015.100.104

URL: https://scialert.net/abstract/?doi=jms.2015.100.104

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