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Journal of Medical Sciences
  Year: 2013 | Volume: 13 | Issue: 7 | Page No.: 537-545
DOI: 10.3923/jms.2013.537.545
The Antiplasmodial Activity of an Herbal Antimalarial, AM 207 in Plasmodium berghei-infected Balb/c Mice: Absence of Organ Specific Toxicity
O.N.K. Martey, O. Shittah-Bay, J. Owusu and L.K.N. Okine

Abstract:
The antiplasmodial activity in P. berghei-infected Balb/c mice and safety in rats of the herbal antimalarial, AM 207 were investigated. The results of the 4-day parasite suppression test showed a high antiplasmodial activity of AM 207 (40 and 200 mg kg-1) comparable to that of Nibima (80 mg kg-1) and chloroquine evidenced by the similar reductions in parasitemia (6.5-6.7%) and degrees of chemo-suppression (48.3-50.6%). In the 6-day suppression test, results showed significant differences in chemo-suppression (p<0.05) between chloroquine (5 mg kg-1) and AM 207 at 20 and 40 mg kg-1 (35.9-52.8%) on one hand and Nibima at 40 and 200 mg kg-1 (42.6-59.2%) on the other. However, AM 207 (200 mg kg-1) and Nibima (80 mg kg-1) showed the highest chemo-suppressions (65.9-71.4%), which were comparable to that of chloroquine (86.6%). The effects of treatments on animal survival time showed that it was increased from 10 days for negative control to a maximum of 23 days for animals receiving AM 207 (20-200 mg kg-1) and 17 days for animals which received Nibima (40-200 mg kg-1). However, no deaths were recorded for chloroquine over the 23 day period. There were no adverse effects of AM 207 on selected rat organs/tissues as evidenced by absence of any significant untoward changes in haematological, urine and serum biochemical parameters as well as organ/body weights. These results indicate that AM 207 at 200 mg kg-1 exhibited antiplasmodial activity comparable to chloroquine and Nibima (80 mg kg-1) and there is no apparent organ specific toxicity associated with it on sub-chronic administration to rats.
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How to cite this article:

O.N.K. Martey, O. Shittah-Bay, J. Owusu and L.K.N. Okine, 2013. The Antiplasmodial Activity of an Herbal Antimalarial, AM 207 in Plasmodium berghei-infected Balb/c Mice: Absence of Organ Specific Toxicity. Journal of Medical Sciences, 13: 537-545.

DOI: 10.3923/jms.2013.537.545

URL: https://scialert.net/abstract/?doi=jms.2013.537.545

 
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