Evaluation of Antidiarrheal Efficacy of Detarium microcarpum Stem Bark Aqueous Extract in Albino Rats


	Journal of Medical Sciences
	Year: 2013 \| Volume: 13 \| Issue: 6 \| Page No.: 477-482 DOI: 10.3923/jms.2013.477.482

Evaluation of Antidiarrheal Efficacy of Detarium microcarpum Stem Bark Aqueous Extract in Albino Rats

M.B. Tijjani, A.A. Barkindo, S. I. Ngulde, B. Wampana and K.A. Sanda

Abstract: Decoction of Detarium microcarpum, used by traditional herbalist as antidiarrheal agents, was investigated for its efficacy. Determination of phytochemical constituents of the aqueous extract was carried qualitatively using standard laboratory procedures. Experimentally-induced diarrhoea and intraluminal pooling and charcoal transit time using castor oil was used as a model for assessing antidiarrheal efficacy of the plant. The result showed that the plant contain alkaloid, tannins, flavonoids and carbohydrates. The extract gave a protection against castor oil induced diarrhoea of 53% compared with standard drug loperamide that gave 91% protection. Intraluminal fluid volume was significantly (p≤0.05) decreased compared negative control. Distance travelled by charcoal meal was found to be significantly (p≤0.05) lower than the negative control and is comparable to with the positive control group that received atropine. The results of this study suggest that the plant was found to possess antidiarrheal effect as claimed by herbalist.

PDF Fulltext XML References Citation Report Citation

How to cite this article:

M.B. Tijjani, A.A. Barkindo, S. I. Ngulde, B. Wampana and K.A. Sanda, 2013. Evaluation of Antidiarrheal Efficacy of Detarium microcarpum Stem Bark Aqueous Extract in Albino Rats. Journal of Medical Sciences, 13: 477-482.

DOI: 10.3923/jms.2013.477.482

URL: https://scialert.net/abstract/?doi=jms.2013.477.482

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		EMBASE
		Google Scholar
		SCIMAGO

Follow @scialert

Science Alert