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Journal of Medical Sciences
  Year: 2013 | Volume: 13 | Issue: 6 | Page No.: 453-458
DOI: 10.3923/jms.2013.453.458
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Controlled Release of Lawsone-intercalated Zn-Al-layered Double Hydroxide

Yamin Yasin and Nur Mushirah Ismail

Lawsone (2-hydroxy-1,4-naphtaquinone) is the biologically active compound which have profound effect on human health. This compound has becoming more important in medicinal chemistry especially in the area of drug development. In this study, a drug-inorganic nanostructured material involving pharmaceutically active compound of lawsone was intercalated between the layers of Zn-Al layered double hydroxide by co-precipitation and ion exchange methods. Powder X-ray Diffraction (XRD) and Fourier Transform Infrared spectra (FTIR) analysis indicate a successful intercalation of lawsone between the layers of layered double hydroxide. TG-DTA analyses shows that the thermal stability of intercalated organic species is largely enhanced due to host-guest interaction as compared to pure form before intercalation. The deintercalation or release of lawsone was found to be rapid initially followed by a more sustained release thereafter and this behavior was found to be dependent on the pH of the release medium. The results suggest that the layered double hydroxide can be used as potential carrier for lawsone with controlled delivery capability.
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How to cite this article:

Yamin Yasin and Nur Mushirah Ismail, 2013. Controlled Release of Lawsone-intercalated Zn-Al-layered Double Hydroxide. Journal of Medical Sciences, 13: 453-458.

DOI: 10.3923/jms.2013.453.458






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