Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Medical Sciences
  Year: 2013 | Volume: 13 | Issue: 4 | Page No.: 296-300
DOI: 10.3923/jms.2013.296.300
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Anti-mutagenic Potential of Nutmeg (Myristica fragrans) in Wistar Rats

U.B. Ekaluo, Y.B. Ibiang, E.V. Ikpeme and P.B. Ekpo

Abstract:
This study was designed to evaluate the anti-mutagenic potential of Myristica fragans (Nutmeg) in male rats. Twenty male wistar rats were randomly distributed into four groups. The treatment groups were administered doses corresponding to 0, 200, 400 and 600 mg kg-1 b.wt. of nutmeg aqueous extract for a period of eight weeks. Data were collected on bone marrow micronucleus index, sperm head abnormality and mutation index. Analysis of variance revealed significant (p<0.05) reductions in sperm head abnormality in the nutmeg treated animals, as compared with the control, in a dose dependent manner. The control had the highest value for sperm head abnormality (6.18±0.55), while 600 mg kg-1 b.wt. group had the lowest value (3.80±0.09). Micronucleus index values in the 600 mg kg-1 b.wt. group (1.40±0.25) was significantly reduced, as compared with the control (3.60±0.51). It was also observed that the mutation indices decreased in a dose dependent manner, from 0.00 in the 0 mg kg-1 b.wt. group to -0.384 in the 600 mg kg-1 b.wt. group. Nutmeg extract showed anti-mutagenic properties, which means the plant contains phyto-antimutagens that could be exploited further in drug development, or as standardized phyto-preparations.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Natural Antimutagens: A Review
How to cite this article:

U.B. Ekaluo, Y.B. Ibiang, E.V. Ikpeme and P.B. Ekpo, 2013. Anti-mutagenic Potential of Nutmeg (Myristica fragrans) in Wistar Rats. Journal of Medical Sciences, 13: 296-300.

DOI: 10.3923/jms.2013.296.300

URL: https://scialert.net/abstract/?doi=jms.2013.296.300

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom