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Journal of Medical Sciences
  Year: 2013 | Volume: 13 | Issue: 3 | Page No.: 221-225
DOI: 10.3923/jms.2013.221.225
 
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The Effect of Desmostachya bipinnata (Linn.) Extract on Physiologically Altered Glycemic Status in Non-diabetic Rats
Upendarrao Golla, Praveen Kumar Gajam and Solomon Sunder Raj B

Abstract:
Desmostachya bipinnata (Linn.) Stapf (Poaceae/Gramineae) is one of the official drugs of ayurvedic pharmacopoeia. Various parts of this plant were used in different parts of world, extensively in Indian traditional and folklore medicine to cure range of human ailments like asthma, jaundice, vaginal discharges, vesicle calculi, diseases of bladder and skin eruptions, also used as analgesic, antipyretic, anti-inflammatory, anti-diabetic, diuretic…etc. Based on its folkloric anti-diabetic effect, the present study was carried out to assess the effect of its hydro-alcoholic extract on glycemic status in non-diabetic rats. In contrast to usual chemical diabetic animal models, alterations in glycemic status were induced by physiological exercises. The results showed that the hydro-alcoholic extract has no effect on euglycemic levels with minimal insignificant alterations. But, the supplementation of this extract in hypoglycemic (food deprivation or swim exercise induced) rats reduced the extent of hypoglycemia significantly. In addition, this extract reduced the degree of hyperglycemia induced by exogenous administration of dextrose significantly. Altogether, the results of current study suggest that the constituents present in Desmostachya bipinnata hydro-alcoholic extract have distinctive property of retaining euglycemic status irrespective of induced glycemic alterations. These significant findings suggest that the concomitant use or supplementation of this plant extract with current therapies will be beneficial to maintain euglycemic status. Taken together, this study supported its folkloric anti-diabetic use and lends pharmacological credence to the ethno-medical use of this plant in traditional system of medicine, demands further studies to elaborate its use, its active constituents and safety.
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How to cite this article:

Upendarrao Golla, Praveen Kumar Gajam and Solomon Sunder Raj B, 2013. The Effect of Desmostachya bipinnata (Linn.) Extract on Physiologically Altered Glycemic Status in Non-diabetic Rats. Journal of Medical Sciences, 13: 221-225.

DOI: 10.3923/jms.2013.221.225

URL: https://scialert.net/abstract/?doi=jms.2013.221.225

 
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