• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Journal of Medical Sciences
  2. Vol 12 (3), 2012
  3. 85-91
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Journal of Medical Sciences

Year: 2012 | Volume: 12 | Issue: 3 | Page No.: 85-91
DOI: 10.3923/jms.2012.85.91

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 220

Authors


Attalla Farag El-Kott

Country: Egypt

Ayman M. Abdel-Aziz

Country: Egypt

Abd El-Karim M. Abd El-Latif

Country: Egypt

Ezz Mohie El-Gamal

Country: Egypt

Abdalla Mohamed Khalil

Country: Egypt

Keywords


  • Bax
  • Nitrate
  • garlic
  • hepatotoxicity
  • superoxide dismutase
  • liver enzymes
Research Article

Amelioration of Nitrate-induced Hepatotoxicity by Allium sativum in Mice

Attalla Farag El-Kott, Ayman M. Abdel-Aziz, Abd El-Karim M. Abd El-Latif, Ezz Mohie El-Gamal and Abdalla Mohamed Khalil
The liver plays a vital role in transforming and clearing chemicals and is susceptible to the toxicity from such agents. The aim of the present study was investigation of the hepatoprotective effect of garlic on Nitrate-induced oxidative damage of liver in mice. Mice were divided into six groups. Control group 1 received tap water. Group 2 received garlic solution at dose 200 mg kg-1 b.wt. Group 3 and group 4 received sodium nitrate at doses 500 and 900 ppm kg-1 b.wt. in drinking water freshly prepared daily. Group 5 and group 6 received sodium nitrate at doses 500 and 900 ppm kg-1 b.wt. and treated with garlic 200 mg kg-1 b.wt. The animals were sacrificed by cervical dislocation on the end of the experiment. Nitrate caused a marked (p<0.001) increase in the levels of lipid peroxidation and superoxide dismutase in the liver. We also observed an increase in the hepatic Activity of Alanine Transaminase (ALT), Aspartate Transaminase (AST). Garlic significantly attenuated these adverse effects of nitrate and proffered a dose-dependent hepatoprotection. The present study showed that nitrate-induced oxidative damage in mice liver was amenable to attenuation by moderate dose of garlic extracts possibly via reduced lipid peroxidation and enhanced antioxidant defense system that was insufficient to prevent and protect Nitrate-induced hepatotoxicity. The 200 mg garlic dose was more effective in treatment of hepatotoxicity-induced by sodium nitrate and decrease the Bax expression. In conclusion, garlic can be given as a dietary supplement to human population exposed to environmental toxicants and can provide protection against toxic effects without being appreciably harmful itself.
PDF Fulltext XML References Citation

How to cite this article

Attalla Farag El-Kott, Ayman M. Abdel-Aziz, Abd El-Karim M. Abd El-Latif, Ezz Mohie El-Gamal and Abdalla Mohamed Khalil, 2012. Amelioration of Nitrate-induced Hepatotoxicity by Allium sativum in Mice. Journal of Medical Sciences, 12: 85-91.

DOI: 10.3923/jms.2012.85.91

URL: https://scialert.net/abstract/?doi=jms.2012.85.91

Related Articles

Efficacy of Allium sativum as Growth Promoter, Immune Booster and Cholesterol-lowering Agent on Broiler Chickens

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved