Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Medical Sciences
  Year: 2012 | Volume: 12 | Issue: 2 | Page No.: 51-56
DOI: 10.3923/jms.2012.51.56
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Morphologic Evaluation of P53 Apoptotic Signaling Responses and Proliferative Activity of Ki-67 in Oral Lichen Planus, Oral Squamous Cell Carcinoma and Normal Specimens

Ashraf Fakhrjou and Seyed Javad Seyed Toutounchi

Abstract:
Oral lichen planus is not a rare condition in human being. This inflammatory disease is generally regarded as a benign pathology; however, transformation toward malignant conditions in some cases has forced many physicians to consider lichen planus as a premalignant entity. This study investigates and compares the rate of Ki-67 and P53 expression in patients with oral lichen planus and oral Squamous Cell Carcinoma (SCC) in comparison with normal subjects. In this prospective study, paraffin-embedded specimens of histopathologically proved oral lichen planus (n = 30), oral SCC (n = 20) and oral buccal mucosa of normal subjects (n = 20) were examined at Tabriz Imam Reza Hospital within a one-year period of time. Monoclonal antibodies against Ki-67 and P53 were used for determining the rate of expression of these two markers. The three groups were matched for patients’ age and gender. Ki-67 was expressed in 26 patients (86.7%) in lichen planus group, in 20 patients (100%) in SCC group and in 4 normal subjects (20%). The rate of Ki-67 positivity was significantly higher in lichen planus and SCC groups than in normal subjects (p<0.001). P53 was positive in 26 patients (86.7%) in lichen planus group, in 20 patients (100%) in SCC group and in 8 normal subjects (40%). The rate of P53 positivity was significantly higher in lichen planus and SCC groups than in normal subjects (p<0.001). In conclusion, this study confirmed that lichen planus could be regarded as a potentially premalignant condition.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Viral, Genetics And Environmental Risk Factors For Hepatocellular Carcinoma In Egypt
  •    Tamoxifen and Melatonin Differentially Influence Apoptosis of Normal Mammary Gland Cells: Ultrastructural Evidence and p53 Expression
  •    Segregation Analysis of p53, c-myc and DNA Ploidy Using Flow Cytometry Among Egyptian Families with Childhood Leukemia
  •    Comparison of Genetic Changes in Transitional and Squamous Bilharzial-Related Bladder Cancers Using Fluorescence in situ Hybridization
How to cite this article:

Ashraf Fakhrjou and Seyed Javad Seyed Toutounchi, 2012. Morphologic Evaluation of P53 Apoptotic Signaling Responses and Proliferative Activity of Ki-67 in Oral Lichen Planus, Oral Squamous Cell Carcinoma and Normal Specimens. Journal of Medical Sciences, 12: 51-56.

DOI: 10.3923/jms.2012.51.56

URL: https://scialert.net/abstract/?doi=jms.2012.51.56

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom