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Journal of Medical Sciences
  Year: 2010 | Volume: 10 | Issue: 4 | Page No.: 93-109
DOI: 10.3923/jms.2010.93.109
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Diabetic Neuropathic Pain: An Update and Novel Pharmacological Strategies for Relief of Pain

R. Taliyan and P.L. Sharma

Diabetic neuropathy is one of the most painful complications of diabetes mellitus, involving progressive neuronal damage and dysfunction and up to 30% of patients with diabetes mellitus developed diabetic neuropathy. Pain caused by diabetic neuropathy is debilitating and often is refractory to classical analgesic, including morphine. The mechanisms underlying cause of diabetic neuropathic pain are complex and both peripheral and central components of the sensory systems are reported to be involved in progression and maintenance of neuropathy. This study summarises data on pathogenesis and on existing and new analgesics such as NSAIDS, opioids, anti-epileptic, membrane stabilising and anti-depressant drugs, that are the mainstay of treatment for alleviating diabetic neuropathic pain. In addition, novel pharmacological approaches and strategies for analgesics such as use of drug combination and their implications will be discussed.
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  •    An Exhaustive Review on Recent Advancement in Pharmaceutical Bioadhesive Used for Systemic Drug Delivery Through Oral Mucosa for Achieving Maximum Pharmacological Response and Effect
  •    Evaluation of Antioxidant, Antinociceptive Activities of Oxalis corniculata in Diabetic Neuropathy Rats
  •    The Effect of Paroxetine, A Selective Serotonin Reuptake Inhibitor, on Blood Glucose Levels in Mice
  •    Beneficial Effect of Cyclosporine in Experimental Diabetes Induced Neuropathic Pain in Rats
How to cite this article:

R. Taliyan and P.L. Sharma, 2010. Diabetic Neuropathic Pain: An Update and Novel Pharmacological Strategies for Relief of Pain. Journal of Medical Sciences, 10: 93-109.

DOI: 10.3923/jms.2010.93.109






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