Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Medical Sciences
  Year: 2010 | Volume: 10 | Issue: 3 | Page No.: 66-70
DOI: 10.3923/jms.2010.66.70
Anti-Oxidative Effect of Simvastatin in Liver and Lung Tissue after Hepatic Ischemia/Reperfusion in Rat
B. Hajipour, M.H. Somi, F. Dibazar, N.A. Asl and A.M. Vatankhah

Abstract:
In this research we studied simvastatin effect on liver and lung tissue anti-oxidant enzymes, 24 h after hepatic I/R. Male Wistar rats were randomly assigned into three groups of fifteen animals in each group. Group 1, the sham group, underwent laparotomy but did not experience I/R; group 2, the I/R group, underwent ischaemia for 30 min and were reperfused for 24 h; Group 3 underwent ischaemia and reperfusion like group 2 but also received 10 mg kg-1 simvastatin dissolved in water by oral gavage for three days before the operation. In animals subjected to hepatic I/R port triad clamped for 30 min following by 24 h reperfusion. Data showed that GPx and SOD levels in liver and lung tissue in I/R+simvastatin group were higher than I/R group significantly (p<0.05). MDA level in I/R group was significantly higher than I/R+simvastatin group in liver and lung tissue significantly (p<0.05). As simvastatin is a safe drug and result of our previous research and also this research show the efficacy of simvastatin pretreatment in decreasing liver and lung oxidative stress after hepatic I/R, so it may be useful in attenuating hepatic I/R injury and it may be effective for performing safer hepatic surgeries.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Liver Ameliorative Effects of the Hydroalcohol Extract of Rosa canina L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar Rats
  •    A Check List on Ichthyofaunal Diversity of Bahuda Estuary, Odisha, East Coast of India
  •    Coenzyme Q10 Ameliorates Statin-related Myotoxicity: A Biochemical and Histological Study
How to cite this article:

B. Hajipour, M.H. Somi, F. Dibazar, N.A. Asl and A.M. Vatankhah, 2010. Anti-Oxidative Effect of Simvastatin in Liver and Lung Tissue after Hepatic Ischemia/Reperfusion in Rat. Journal of Medical Sciences, 10: 66-70.

DOI: 10.3923/jms.2010.66.70

URL: https://scialert.net/abstract/?doi=jms.2010.66.70

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

       

       

Curve Bottom