Subscribe Now Subscribe Today
Science Alert
Curve Top
Journal of Medical Sciences
  Year: 2009 | Volume: 9 | Issue: 2 | Page No.: 87-92
DOI: 10.3923/jms.2009.87.92
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Attenuation of Experimental Gastric Ulceration by Sulfadoxine-pyrimethamine in Albino Rats

S.B. Olaleye and K.O. Ajeigbe

The aim of the present study was to investigate the effect of the therapeutic dose of sulfadoxine-pyrimethamine on experimentally induced gastric ulceration in albino rats. Rats were given sulfadoxine-pyrimethamine (22.5 mg kg-1) intramuscularly for 24 h after formation of ulcers induced by indomethacin or by acidified ethanol. Upon sacrifice, colorimetric assays were applied to determine the concentration of protein and mucus, activities of catalase and superoxide dismutase and lipid peroxidation in homogenized gastric mucosal samples. Sulfadoxine-pyrimethamine was observed to alleviate gastric lesions produced either by indomethacin or acidified ethanol. Also, the drug seemed to attenuate the indomethacin or acidified ethanol induced effects on gastric juice volume, pH and acid output. On the other hand, thiobarbituric acid reactants (TBAR) was decreased and superoxide dismutase (SOD) and catalase (CAT) activities increased in the gastric mucosal samples, though, however, protein and mucus concentrations remained statistically unchanged. The use of sulfadoxine-pyrimethamine may be safe on the integrity of the stomach, especially in existing gastric ulcers. It ameliorates oxidative stress in the gastric mucosa caused by indomethacin and acidified ethanol.
PDF Fulltext XML References Citation Report Citation
  •    Antiulcer Effects of Alpha Lipoic Acid on Gastric Acid Secretion and Mucosal Defense Factors in Rats
How to cite this article:

S.B. Olaleye and K.O. Ajeigbe, 2009. Attenuation of Experimental Gastric Ulceration by Sulfadoxine-pyrimethamine in Albino Rats. Journal of Medical Sciences, 9: 87-92.

DOI: 10.3923/jms.2009.87.92






Curve Bottom