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Circulating Concentrations of Leptin Hormone, Soluble Leptin Receptor and Free Leptin Index in Obese Egyptian Women Before and after Diet Therapy |
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Salwa M. El-Shebini,
Lobna A. Ghattas,
Hamed I. Mohamed,
Maha I.A. Moaty,
Salwa T. Tapozada and Laila M. Hanna |
Abstract:
It has been proposed that obesity is associated with resistance to the
biological effects of leptin hormone. The aim of this study was to demonstrate
the effect of obesity on both serum leptin and its soluble receptor and
to evaluate the effect of consumption of a special food formula combined
with a restricted diet for obesity management. Thirty-two obese women
volunteered to test a natural food formula in combination with a balanced
hypo caloric-diet (both supply 900-1000 Kcal day-1) shared
in a short term study, which lasted for four weeks. The formula was composed
of whole sweet potato and carrot which were reduced to a flour form in
2:1 ratio and consumed as a pudding (20 g flour +100 mL boiled skimmed
milk) for daily breakfast. Sweet potatoes and carrots are considered as
a good source of dietary fibers, complex carbohydrates, antioxidants and
phytochemicals. Subjects were divided into twenty-two obese women (group
1) with mean age (41.8±2.91 years) and body mass index (34.87±1.21),
who followed the diet plus the pudding mixture; while ten obese women
as a control (group 2) had a mean age of (43.4±2.28) and a body
mass index of (36.57±1.31); who only followed the same diet. Relevant
anthropometric measurements together with some biochemical parameters
were determined before, after two and four weeks from the start of the
regimen. Results showed although both groups lost weight comparably, group
1 (p<0.01,-3.55%), group2 (p<0.01,-2.01%), yet there were differences
between them regarding serum leptin where in group 1 it was significantly
decreased (p<0.01, -29.77%), with a concurrent increase in the serum
soluble leptin receptor (p<0.05, +15.99%); in contrast to decreased
levels of both leptin (-3.33%) and soluble leptin receptor (p<0.001,
-5.05%) in group 2. Triglycerides levels were decreased (P<0.05,-22.62%)
in group 1 in contrast to an increase (p<0.05, +39.40%) in group 2.
In conclusion, incorporating custom-tailored food supplement in a slimming
diet aiming at a quality weight loss that provides a healthier stable
and durable metabolic environment should be considered.
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How to cite this article:
Salwa M. El-Shebini, Lobna A. Ghattas, Hamed I. Mohamed, Maha I.A. Moaty, Salwa T. Tapozada and Laila M. Hanna, 2009. Circulating Concentrations of Leptin Hormone, Soluble Leptin Receptor and Free Leptin Index in Obese Egyptian Women Before and after Diet Therapy. Journal of Medical Sciences, 9: 219-226.
DOI: 10.3923/jms.2009.219.226
URL: https://scialert.net/abstract/?doi=jms.2009.219.226
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