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Journal of Medical Sciences
  Year: 2008 | Volume: 8 | Issue: 5 | Page No.: 519-522
DOI: 10.3923/jms.2008.519.522
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IgA Deficiency Frequency in Zahedan Blood Transfusion Services Donors

R. Nosratabadi, E.S. Moghadam, M.K. Arababadi, S. Khosravi and G. Hassanshahi

This study was performed to examine the prevalence of IgA deficiency in blood donors in Zahedan Province of Iran. Following transfusion of IgA containing blood or its components to an IgA deficient individual, antibody will be produced against received IgA and causes sever allergic reaction. Therefore it`s worth nothing to have, IgA deficiency frequency even at a low level in blood donors of different races to plan for safe blood. In this experimental study, blood samples were collected from 3837 volunteer blood donors during one year. 3449 (89.9%) of the 3837 blood donors screened were males and 388 (10.1%) were females. 1464 (38.18%) were single and 2373 (61.82%) married. The demographic questioner was filled out for each donor by a physician. Then the serum samples were tested for IgA titer by nephlometry and SRID techniques and IgA level in positive samples were analyzed by ELISA (RADIM, Italy). Finally data were analyzed by Chi-square and t-test. According to present results only, one donor (0.03%) was found to have IgA less than 5 mg dL-1 and 11 (0.3%) cases had IgA between 5-30 mg dL-1 while 3825 (99.67%) had IgA more than 30 mg dL-1. Present results showed a low prevalence rate of IgA deficiency in Sistan and Baluchestan region of Iran. Therefore, anaphylactic reactions could probably be due to other factors in the individuals that receive blood products. In the other hand the results from this study help blood transfusion services directors and managers to find high risk families and individuals with IgA deficiency to receive safe blood and blood components in case of need.
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How to cite this article:

R. Nosratabadi, E.S. Moghadam, M.K. Arababadi, S. Khosravi and G. Hassanshahi, 2008. IgA Deficiency Frequency in Zahedan Blood Transfusion Services Donors. Journal of Medical Sciences, 8: 519-522.

DOI: 10.3923/jms.2008.519.522






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