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Journal of Medical Sciences
  Year: 2008 | Volume: 8 | Issue: 3 | Page No.: 216-221
DOI: 10.3923/jms.2008.216.221
 
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C-511T Polymorphism of Interleukin-1 β Gene is Not Associated in Type 2 Diabetes Mellitus-A Study in Malaysian Population

R. Vasudevan, Patimah Ismail, Johnson Stanslas and Norashikin Shamsudin

Abstract:
The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM, 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population.
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How to cite this article:

R. Vasudevan, Patimah Ismail, Johnson Stanslas and Norashikin Shamsudin, 2008. C-511T Polymorphism of Interleukin-1 β Gene is Not Associated in Type 2 Diabetes Mellitus-A Study in Malaysian Population. Journal of Medical Sciences, 8: 216-221.

DOI: 10.3923/jms.2008.216.221

URL: https://scialert.net/abstract/?doi=jms.2008.216.221

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