Subscribe Now Subscribe Today
Science Alert
Curve Top
Journal of Medical Sciences
  Year: 2007 | Volume: 7 | Issue: 5 | Page No.: 901-904
DOI: 10.3923/jms.2007.901.904
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Effects of Lead Toxicity on Free Radical Production in Rats

I.M. Alhazza and A.S.A. Haffor

Heavy metal toxicity causes impairment of variety of cellular process. Cellular failure to maintain balance between the generation and elimination of reactive molecules results in tissue damage. The purpose of this study was to determine the effects of Lead (BP) toxicity on Free Radicals (FR) production. Sixteen adult rats matched with age were randomly assigned to two groups, control and experimental. The experimental group was injected (IP) 1 mg kg-1 of body weight BP daily for seven days. Mean FR in the control group was 206.13±12.39 CARR U. In BP treated group the mean (±SEM) FR rose to 324.13±12.61 CARR U. The change in FR corresponds to 57% increase in the lead treated group. Thus, BP toxicity exposure mediates mitochondria damage and the subsequent oxidative stress. Based on the results of the present study, it can be concluded that BP toxicity causes elevation of Reactive Oxygen Species (ROS) which mediate inhibition of mitochondrial respiration in rats.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

I.M. Alhazza and A.S.A. Haffor, 2007. Effects of Lead Toxicity on Free Radical Production in Rats. Journal of Medical Sciences, 7: 901-904.

DOI: 10.3923/jms.2007.901.904






Curve Bottom