Effects of Nitric Oxide and Arginine Vasopressin on Water Intake Induced by Central Angiotensin II. Part 1


	Journal of Medical Sciences
	Year: 2007 \| Volume: 7 \| Issue: 5 \| Page No.: 845-849 DOI: 10.3923/jms.2007.845.849

Effects of Nitric Oxide and Arginine Vasopressin on Water Intake Induced by Central Angiotensin II. Part 1

Wilson Abrao Saad, Ismael Francisco Motta Sigueira Guarda , Luis Antonio de Arruda Camargo , Talmir Augusto Faria Brizola dos Santos and William Abrao Saad

Abstract: We determined the effects of AT₁and AT₂ (selective no peptides antagonists angiotensin receptors), arginine vasopressin V₁ receptor antagonist as well as L-arginine, a nitric oxide donor and N^W-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, injected into supraoptic nucleus (SON) on water and sodium intake induced by the injection of angiotensin II (ANGII). Male Holtzman rats weighing 200-250 g with canulae implanted into the SON were used. The drugs were injected in 0.5 μL over 30-60 sec. The water intake after injection of saline SAL+SAL 0.15 M NaCl was 0.40±0.1 mL 2 h^-1; SAL+ANGII increase water intake. Losartan decreased the water intake induced by ANGII. PD123319 injected prior to produce no change in water intake induced by ANGII. AVPA prior to ANGII reduced the water intake with a less intensity than losartan. L-arginine prior to ANGII decreases the water intake at a same intensity than losartan. L-NAME prior to ANGII potentiated the dipsogenic effect of ANGII. Losartan injected simultaneously with L-arginine prior to ANGII blocked the dipsogenic effect of ANGII. These results confirm the importance of SON in the control of water intake and strongly suggest that AT₁, V₁ receptors interact with nitrergic pathways within the SON influencing the dipsogenic effect of ANGII.

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How to cite this article:

Wilson Abrao Saad, Ismael Francisco Motta Sigueira Guarda , Luis Antonio de Arruda Camargo , Talmir Augusto Faria Brizola dos Santos and William Abrao Saad , 2007. Effects of Nitric Oxide and Arginine Vasopressin on Water Intake Induced by Central Angiotensin II. Part 1. Journal of Medical Sciences, 7: 845-849.

DOI: 10.3923/jms.2007.845.849

URL: https://scialert.net/abstract/?doi=jms.2007.845.849

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