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Journal of Medical Sciences
  Year: 2007 | Volume: 7 | Issue: 2 | Page No.: 238-242
DOI: 10.3923/jms.2007.238.242
 
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Calcium Ions Influences Smooth Muscle Relaxant Response to Aqueous Extract of Portulaca oleracea

F.S. Oluwole and K.O. Oyedeji

Abstract:
Aqueous extract of the leaf and stem of Portulaca oleracea (AEPO) was tested on isolated Guinea Pig Ileum (GPI) preparation. The extract was also tested on ileal smooth muscles of guinea pig precontracted with 10-5 g mL-1 carbachol and in vivo motility assessment in mice was investigated. The study showed the following order of sensitivity of GPI preparation to the drugs; AEPO> histamine> acetylcholine. Both atropine and promethazine abolished the contractile responses of GPI to AEPO only at low doses; 1x10-5 to 10-3 g mL-1 while nifedipine completely inhibited ileal muscle contractions to AEPO. The extract also caused relaxation to carbachol-sustained contractions. In vivo study demonstrated dose dependent reduction in peristaltic index in mice. From the results of these studies, the mechanism of action of the extract on relaxant response of GPI to AEPO may be dependent on Ca2+ antagonism.
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How to cite this article:

F.S. Oluwole and K.O. Oyedeji, 2007. Calcium Ions Influences Smooth Muscle Relaxant Response to Aqueous Extract of Portulaca oleracea. Journal of Medical Sciences, 7: 238-242.

DOI: 10.3923/jms.2007.238.242

URL: https://scialert.net/abstract/?doi=jms.2007.238.242

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