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Journal of Medical Sciences
  Year: 2007 | Volume: 7 | Issue: 2 | Page No.: 222-227
DOI: 10.3923/jms.2007.222.227
 
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IL-1β+3954 Genetic Polymorphism Association with Generalized Aggressive Periodontitis in Khorasan-Iran Province

H.R. Arab, J. Tavakkol-Afshari, M. Radvar, A. Moeintaghavi, N. Sargolzaei, A. Rigi and M. Shirkhani

Abstract:
The aim of this study was to investigate the relationship between IL-1β+3954 gene polymorphism and Generalized Aggressive Periodontitis (GAP). This study included 25 patients diagnosed as GAP from Khorasan province and 18 periodontally healthy controls. They were referred to Periodontology Department of Mashad Dental School. Extracted DNA from peripheral blood was evaluated by PCR-RFLP method. Data were analyzed using Chi-square test, Fisher`s exact test and two sample t-tests. There was no significant association between IL-1β+3954 genotype and GAP disease (p = 0.419). There was no significant association between IL-1β+3954 alleles and GAP disease either (p = 0.370). However, there was some trend for greater of 1.1 genotype and allele 1 prevalence among GAP patients compared to controls (56 and 44.4% for 1.1 genotype among GAP and control patients respectively, 78 and 69.4% for allele 1 frequency among GAP and controls, respectively). The frequencies of 1.1 genotype and allele 1 in the population of this study were 51.2 and 74.4%, respectively. The lack of any association between IL-1β+3954 polymorphism and GAP, in the population presented here, brings into doubt the usefulness of this gene as a marker of susceptibility to GAP. To elucidate this relationship, more research is necessary.
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How to cite this article:

H.R. Arab, J. Tavakkol-Afshari, M. Radvar, A. Moeintaghavi, N. Sargolzaei, A. Rigi and M. Shirkhani, 2007. IL-1β+3954 Genetic Polymorphism Association with Generalized Aggressive Periodontitis in Khorasan-Iran Province. Journal of Medical Sciences, 7: 222-227.

DOI: 10.3923/jms.2007.222.227

URL: https://scialert.net/abstract/?doi=jms.2007.222.227

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