Submit Manuscript

Journal of Medical Sciences

Year: 2007 | Volume: 7 | Issue: 2 | Page No.: 187-194
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 177

Authors

H.M. Salahdeen

A.R.A. Alada

Keywords

Research Article

Cardiovascular Response to Angiotensin II and Captopril in Normal and Diabetic Rats Loaded with Salt

H.M. Salahdeen and A.R.A. Alada
The results of the present study demonstrated that dietary salt loading in normal and diabetic rats increased the blood pressure, blood volume, plasma sodium level and sensitivity of cardiovascular responses to angiotensin II and Captopril. This probably suggests that salt loading interferes with the mechanism regulating blood pressure in salt loaded rats either by decreasing the secretion of vasodilators mediators, increasing the production of vasoconstrictors, increasing the sensitivity to vasoconstrictors and/or resistance of vascular smooth muscle to endothelial vasodilators. It was then concluded that the increase in the sensitivity to angiotensin II and hypervolaemia, probably caused the development and sustenance of hypertension observed in salt loading diabetic rats.
PDF Fulltext XML References Citation

Leave a Comment

Your email address will not be published. Required fields are marked *