
	Journal of Medical Sciences
	Year: 2007 \| Volume: 7 \| Issue: 2 \| Page No.: 187-194 DOI: 10.3923/jms.2007.187.194

Cardiovascular Response to Angiotensin II and Captopril in Normal and Diabetic Rats Loaded with Salt

H.M. Salahdeen and A.R.A. Alada

Abstract: The results of the present study demonstrated that dietary salt loading in normal and diabetic rats increased the blood pressure, blood volume, plasma sodium level and sensitivity of cardiovascular responses to angiotensin II and Captopril. This probably suggests that salt loading interferes with the mechanism regulating blood pressure in salt loaded rats either by decreasing the secretion of vasodilators mediators, increasing the production of vasoconstrictors, increasing the sensitivity to vasoconstrictors and/or resistance of vascular smooth muscle to endothelial vasodilators. It was then concluded that the increase in the sensitivity to angiotensin II and hypervolaemia, probably caused the development and sustenance of hypertension observed in salt loading diabetic rats.

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How to cite this article:

H.M. Salahdeen and A.R.A. Alada, 2007. Cardiovascular Response to Angiotensin II and Captopril in Normal and Diabetic Rats Loaded with Salt. Journal of Medical Sciences, 7: 187-194.

DOI: 10.3923/jms.2007.187.194

URL: https://scialert.net/abstract/?doi=jms.2007.187.194

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