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Journal of Medical Sciences
  Year: 2007 | Volume: 7 | Issue: 8 | Page No.: 1310-1314
DOI: 10.3923/jms.2007.1310.1314
 
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Plasma Level of Tissue Factor Pathway Inhibitor in Children With Idiopathic Recurrent Epistaxis (Nosebleeds)

Eitedal M. Daoud, Reda M. Daoud , Lobna M. Saber and Maha M. Saber

Abstract:
Previously TFPI has never been studied in childhood nosebleeds. In this study, we determined the free plasma level of TFPI in children with recurrent attacks of idiopathic epistaxis (nosebleeds), during active attacks of nasal bleeding and 24-48 h after treatments (remission state). We investigated 50 children. They were divided into 2 groups. Group 1, 20 children during active attack of nosebleeds. Group 2, 30 children during remission state. All patients enrolled in this study were selected from ENT-Out Patient Clinics Al-Azhar University Hospitals Cairo, Egypt (El-Hossain Hospital). Results were compared to 30 healthy controls age and sex matched. Free plasma TFPI was measured by Enzyme-Linked Immunosorbent Assay (ELISA) in all patients and healthy control child. There was high significant increase of free plasma TFPI levels in children during acute nosebleeds and in remission state (group 1 and group 2) in comparison to healthy control children (group 3) (p< 0.0001, p< 0.0001), respectively. The highest level of free plasma TFPI was recorded in group 1, followed by children in group 2. In the same time, TFPI level in group 1 of children was highly significantly increased as compared to the level in children in group 2 (p< 0.001) As regard gender, there were highly significant increased in free plasma levels of TFPI in both groups (group 1 and 2) as compared to the same genders of the control children (group 3) (p< 0.001 and p< 0.001), respectively. Comparing hemoglobin levels, there was significant decrease in its level in children in group 1 and II when compared to children in group 3 (control) (p< 0.01 and p< 0.01). From the present study we concluded that, free plasma level of TFPI is increased in children with idiopathic recurrent nosebleeds, comparable to healthy control children matched for age and sex. The highest level of free TFPI was recorded in children with active attacks of nosebleeds. This high level of TFPI may reflects the degree of endothelial cells dysfunction in this group of children and the state of vascular wall cells in microvasculature of their Little`s areas. Further studies are recommended to clarify more the role of the increased free TFPI in pediatric cases with recurrent idiopathic epistaxis and its effect on endothelial cells function as well as vascular wall cells integrity in microvascular circulation.
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How to cite this article:

Eitedal M. Daoud, Reda M. Daoud , Lobna M. Saber and Maha M. Saber , 2007. Plasma Level of Tissue Factor Pathway Inhibitor in Children With Idiopathic Recurrent Epistaxis (Nosebleeds). Journal of Medical Sciences, 7: 1310-1314.

DOI: 10.3923/jms.2007.1310.1314

URL: https://scialert.net/abstract/?doi=jms.2007.1310.1314

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