Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Medical Sciences
  Year: 2006 | Volume: 6 | Issue: 4 | Page No.: 701-703
DOI: 10.3923/jms.2006.701.703
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Effect of Different Doses of Black Caraway (Carum carvi L.) Oil on the Levels of Serum Creatinine in Alloxan Induced Diabetic Rats

A.C. Ene , D.N. Bukbuk and O.O. Ogunmola

Abstract:
The effect of different doses of black caraway (Carum carvi L.) oil on the levels of serum creatinine in alloxan induced-diabetic rats was studied. Forty white male albino rats of the Winster strain weighing between 125 and 215 g were used. Diabetes was induced in the experimental rats with alloxan (70 mg kg-1) body weight. Five rats were randomly assigned into each group (Group I - VIII). Group I rats served as the normal control, Group II served as the caraway control, whereas, Group III rats served as the diabetic control. Groups IV to VIII were the test groups. The test group rats were administered different doses of the black caraway oil thus; 5, 10, 20, 40 and 80 mg kg-1 body weight , respectively. The experiment lasted for a period of 10 weeks. The blood glucose and serum creatinine levels in the different groups were assayed. There was a statistically significant increase (p<0.0001) in the levels of blood glucose and serum creatinine in the diabetic control (Group III). These levels were significantly reduced by the administration of 10 mg kg-1 wet weight of the black caraway oil group (Group V) compared to the diabetic control (Group III) and the other treatment groups (Groups IV, VI-VIII). It can be concluded that the black caraway oil significantly lowers the serum creatinine levels in the diabetic rats, but its effect can be said to be dose dependent.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

A.C. Ene , D.N. Bukbuk and O.O. Ogunmola , 2006. Effect of Different Doses of Black Caraway (Carum carvi L.) Oil on the Levels of Serum Creatinine in Alloxan Induced Diabetic Rats. Journal of Medical Sciences, 6: 701-703.

DOI: 10.3923/jms.2006.701.703

URL: https://scialert.net/abstract/?doi=jms.2006.701.703

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom