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Journal of Medical Sciences
  Year: 2006 | Volume: 6 | Issue: 3 | Page No.: 474-479
DOI: 10.3923/jms.2006.474.479
 
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Soluble Adhesion Molecules in Juvenile Idiopathic Arthritis: Relation to Activity and Clinical Subtype

Mohammad Al-Haggar, Mohamed Ragab , Manal Awad and Rizk Al-Baz

Abstract:
The present research aimed to evaluate serum Adhesion Molecules (AMs) in patients with Juvenile Idiopathic Arthritis (JIA) to correlate their values with disease activity in different clinical subtypes. Serum levels of some soluble AMs (E-selectin, sICAM1 and sVCAM1) wereassayed by ELISA in 37 patients with JIA both during activity and after remission. Other activity parameters like sedimentation rate and leukocytic counts were tested as well. Twentyhealthy children of matched age and sex were taken as control. Serum E-selectin was found significantly higher in JIA compared to control (in all subtypes across all disease stages), with significant drop after remission, yet not reached the normal values. These changes were more evident in systemic JIA compared to other subtypes. Serum ICAM1 and VCAM1 showed the same changes in relation to control and to the disease activity. We can conclude that systemic JIA is associated with higher levels of soluble AMs thus explaining the perpetual inflammatory process and hence the remissions and exacerbations which are usually associated with higher morbidity in systemic JIA than in the other subtypes. We recommend following JIA patients until laboratory remission (normalization of serum AMs) to correlate AMs levels to clinical course aiming to put forward a therapeutic plan.
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How to cite this article:

Mohammad Al-Haggar, Mohamed Ragab , Manal Awad and Rizk Al-Baz , 2006. Soluble Adhesion Molecules in Juvenile Idiopathic Arthritis: Relation to Activity and Clinical Subtype. Journal of Medical Sciences, 6: 474-479.

DOI: 10.3923/jms.2006.474.479

URL: https://scialert.net/abstract/?doi=jms.2006.474.479

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