Single Nucleotide Polymorphism Associated with Late-onset Alzheimer’s Disease

Research Article

Single Nucleotide Polymorphism Associated with Late-onset Alzheimer’s Disease

Abdulaziz Ali A. Al-Khedhairy, Misbahul Arfin, Bassam A. Alahmadi and Mohamed A. Al-Jumah

Single Nucleotide Polymorphisms (SNPs) in presenilin-1 gene (PS1) were characterized in Saudi patients afflicted with Alzheimer’s Disease (AD) using Polymerase Chain Reaction (PCR) and automated DNA sequencing methods. Genomic DNA was extracted from blood of both patients and normal individuals using organic extraction methods. Genomic DNA was amplified for all PS1 exons and intronic boundaries. Fragments were sequenced and compared with the sequences of the respective exons of normal individuals as well as the data available in GenBank. Comparison yielded the discovery of two SNPs, T56240G and T56454C in 5′ and 3′ intronic regions of exon 8 of late-onset AD Saudi patients, respectively.

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Abdulaziz Ali A. Al-Khedhairy, Misbahul Arfin, Bassam A. Alahmadi and Mohamed A. Al-Jumah, 2005. Single Nucleotide Polymorphism Associated with Late-onset Alzheimer’s Disease. Journal of Medical Sciences, 5: 275-279.

DOI: 10.3923/jms.2005.275.279

URL: https://scialert.net/abstract/?doi=jms.2005.275.279

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Authors

Abdulaziz Ali A. Al-Khedhairy

Misbahul Arfin

Bassam A. Alahmadi

Mohamed A. Al-Jumah

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Research Article

Single Nucleotide Polymorphism Associated with Late-onset Alzheimer’s Disease

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