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Journal of Medical Sciences
  Year: 2005 | Volume: 5 | Issue: 3 | Page No.: 181-185
DOI: 10.3923/jms.2005.181.185
 
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Effect of Co-trimazine on the Survival of Brucella abortus in Mouse Peritoneal Macrophages

Abbas Rezaee, Majid Ansari and Reza Shahpori

Abstract:
The efficacy of co-trimazine was studied in vitro in mouse macrophages infected with Brucella abortus. The macrophages first were allowed to phagocytes the Brucella abortus. After uptake period, extra cellular bacteria were removed by gentamicin. The bacteria were able to grow in the cells with an apparent multiplication rate of about 90min. Bactericidal activity was measured after treatment of the macrophages with co-trimazine. Co-trimazine showed a bactericidal effect at MIC concentration used, (6.32 mg L-1 trimethoprim and 8.19 mg L-1 sulphadiazine) and a total killing of intracellular bacteria at concentrations of 9.33 mg L-1 trimethoprim and 12.46 mg L-1 sulphadiazine). Results of the study show that co-trimazine was effective on intracellular Brucella abortus.
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How to cite this article:

Abbas Rezaee, Majid Ansari and Reza Shahpori , 2005. Effect of Co-trimazine on the Survival of Brucella abortus in Mouse Peritoneal Macrophages. Journal of Medical Sciences, 5: 181-185.

DOI: 10.3923/jms.2005.181.185

URL: https://scialert.net/abstract/?doi=jms.2005.181.185

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