Benomyl, a fungicide of the benzimidazole group applied against a wide range of fungal diseases of crops and vegetables. The effects of benomyl on the hepatic tissue of albino rats were investigated. Treating rats with benomyl at a dose level of 1/10 LD50 three times/week for three weeks induced various histopathological changes in the liver, such as hepatic tissue impairment, cytoplasmic vacuolization of the hepatocytes, leucocytic infiltrations, congestion of blood vessels and fatty degeneration. Histochemical investigations revealed reduction in total carbohydrates, total proteins and nucleic acids (DNA, RNA) in the hepatic cells. These alterations were time-dependent and were obvious in animals treated with benomyl for 3 weeks. It is speculated that one or more metabolites of benomyl may be responsible for the hepatotoxicity recorded in the present work. PDFFulltextXMLReferencesCitation
How to cite this article
Saber A. Sakr, Hany A. Abdel Samei and Maha E. Soliman, 2004. Exploring Hepatotoxicity of Benomyl: Histological and Histochemical Study on Albino Rats. Journal of Medical Sciences, 4: 77-83.