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Journal of Medical Sciences
  Year: 2004 | Volume: 4 | Issue: 2 | Page No.: 164-169
DOI: 10.3923/jms.2004.164.169
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Effects of O2 Breathing on Cardiac Mitochondrial, GOT and Free Radical Production

A.S.A. Haffor

The purpose of this study was to examine the effects of oxygen breathing on cardiac mitochondrial injury, GOT and free radical (FR) production. Twelve rats (SRW) were exposed to oxygen (100% O2) breathing, for 4-6 h daily for 4.5 weeks. Ultrastructure examination was conducted by transmission electron microscope, GOT and FR determinations were conducted using the kinetic method. Myocardial ultrastructure examination showed mitochondrial hyperplasia, cristae dislocation, matrical lamina formation and secondary lysosomal structure. Baseline FR and GOT were 179.5 Carr U and 35.43 U L-1, respectively. Following exposure to oxygen breathing FR increased to 348.50 Carr U and GOT increased to 75.38 U L-1. Both the changes in FR and in GOT were significant (P<0.05). The regression of GOT on FR after oxygen breathing was significant (P<0.05). Mitochondrial and cellular pathological abnormalities were attributed to oxidative damage, induced by oxygen breathing that resulted in increased rate of free radicals production and the subsequent elevation in GOT.
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How to cite this article:

A.S.A. Haffor , 2004. Effects of O2 Breathing on Cardiac Mitochondrial, GOT and Free Radical Production. Journal of Medical Sciences, 4: 164-169.

DOI: 10.3923/jms.2004.164.169






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